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Table 3 Risk of first stroke (total and subtypes) associated with plasma selenium concentrations in all participantsa

From: Sex difference in the association between plasma selenium and first stroke: a community-based nested case-control study

Selenium, ng/mL Cases/controls Model 1   Model 2  
OR (95% CI) P value OR (95% CI) P value
First total stroke
Tertiles
 T1 (< 79.1) 420/417 Ref.   Ref.  
 T2 (79.1 to < 94.1) 434/402 1.07 (0.88, 1.30) 0.516 1.02 (0.82, 1.26) 0.891
 T3 (≥ 94.1) 401/436 0.90 (0.73, 1.11) 0.317 0.77 (0.61, 0.97) 0.027
Categories
 T1–T2 (< 94.1) 854/819 Ref.   Ref.  
 T3 (≥ 94.1) 401/436 0.87 (0.73, 1.04) 0.119 0.76 (0.63, 0.93) 0.007
Ischemic stroke
Tertiles
 T1 (< 79.1) 360/363 Ref.   Ref.  
 T2 (79.1 to < 94.1) 372/340 1.10 (0.89, 1.35) 0.376 1.05 (0.83, 1.33) 0.672
 T3 (≥ 94.1) 347/376 0.92 (0.74, 1.14) 0.444 0.78 (0.60, 0.99) 0.045
Categories
 T1–T2 (< 94.1) 732/703 Ref.   Ref.  
 T3 (≥ 94.1) 347/376 0.87 (0.72, 1.06) 0.163 0.75 (0.61, 0.93) 0.009
Hemorrhagic stroke
Tertiles
 T1 (< 79.1) 58/54 Ref.   Ref.  
 T2 (79.1 to < 94.1) 60/61 0.88 (0.50, 1.57) 0.673 0.76 (0.38, 1.55) 0.455
 T3 (≥ 94.1) 53/56 0.85 (0.47, 1.54) 0.587 0.72 (0.35, 1.48) 0.371
Categories
 T1–T2 (< 94.1) 118/115 Ref.   Ref.  
 T3 (≥ 94.1) 53/56 0.92 (0.57, 1.47) 0.718 0.85 (0.48, 1.50) 0.577
  1. a ORs of first stroke (total), first ischemic, and hemorrhagic stroke in relation to plasma selenium (tertiles) were analyzed using conditional logistic regression models. Model 1 is conditioned on the matching factors of age and sex; model 2 is conditioned on the matching factors of age and sex, as well as adjusted for BMI, baseline SBP, baseline DBP, smoking status, alcohol consumption, labour intensity, baseline total homocysteine, vitamin E, fasting glucose, estimated glomerular filtration rate (eGFR), anti-platelet drugs, lipoprotein-lowering drugs, glucose-lowering drugs, anti-hypertensive drugs, self-reported hypertension, self-reported atrial fibrillation, self-reported diabetes, and self-reported hyperlipidemia.