Sex difference in the association between plasma selenium and first stroke: a community-based nested case-control study

Table 3 Risk of first stroke (total and subtypes) associated with plasma selenium concentrations in all participants^a

Selenium, ng/mL	Cases/controls	Model 1		Model 2
Selenium, ng/mL	Cases/controls	OR (95% CI)	P value	OR (95% CI)	P value
First total stroke
Tertiles
T1 (< 79.1)	420/417	Ref.		Ref.
T2 (79.1 to < 94.1)	434/402	1.07 (0.88, 1.30)	0.516	1.02 (0.82, 1.26)	0.891
T3 (≥ 94.1)	401/436	0.90 (0.73, 1.11)	0.317	0.77 (0.61, 0.97)	0.027
Categories
T1–T2 (< 94.1)	854/819	Ref.		Ref.
T3 (≥ 94.1)	401/436	0.87 (0.73, 1.04)	0.119	0.76 (0.63, 0.93)	0.007
Ischemic stroke
Tertiles
T1 (< 79.1)	360/363	Ref.		Ref.
T2 (79.1 to < 94.1)	372/340	1.10 (0.89, 1.35)	0.376	1.05 (0.83, 1.33)	0.672
T3 (≥ 94.1)	347/376	0.92 (0.74, 1.14)	0.444	0.78 (0.60, 0.99)	0.045
Categories
T1–T2 (< 94.1)	732/703	Ref.		Ref.
T3 (≥ 94.1)	347/376	0.87 (0.72, 1.06)	0.163	0.75 (0.61, 0.93)	0.009
Hemorrhagic stroke
Tertiles
T1 (< 79.1)	58/54	Ref.		Ref.
T2 (79.1 to < 94.1)	60/61	0.88 (0.50, 1.57)	0.673	0.76 (0.38, 1.55)	0.455
T3 (≥ 94.1)	53/56	0.85 (0.47, 1.54)	0.587	0.72 (0.35, 1.48)	0.371
Categories
T1–T2 (< 94.1)	118/115	Ref.		Ref.
T3 (≥ 94.1)	53/56	0.92 (0.57, 1.47)	0.718	0.85 (0.48, 1.50)	0.577

^a ORs of first stroke (total), first ischemic, and hemorrhagic stroke in relation to plasma selenium (tertiles) were analyzed using conditional logistic regression models. Model 1 is conditioned on the matching factors of age and sex; model 2 is conditioned on the matching factors of age and sex, as well as adjusted for BMI, baseline SBP, baseline DBP, smoking status, alcohol consumption, labour intensity, baseline total homocysteine, vitamin E, fasting glucose, estimated glomerular filtration rate (eGFR), anti-platelet drugs, lipoprotein-lowering drugs, glucose-lowering drugs, anti-hypertensive drugs, self-reported hypertension, self-reported atrial fibrillation, self-reported diabetes, and self-reported hyperlipidemia.

ISSN: 2042-6410