|
Selenium, ng/mL
|
Cases/controls
|
Model 1
| |
Model 2
| |
|---|
|
OR (95% CI)
|
P value
|
OR (95% CI)
|
P value
|
|---|
|
First total stroke
|
|
Tertiles
|
|
T1 (< 79.1)
|
420/417
|
Ref.
| |
Ref.
| |
|
T2 (79.1 to < 94.1)
|
434/402
|
1.07 (0.88, 1.30)
|
0.516
|
1.02 (0.82, 1.26)
|
0.891
|
|
T3 (≥ 94.1)
|
401/436
|
0.90 (0.73, 1.11)
|
0.317
|
0.77 (0.61, 0.97)
|
0.027
|
|
Categories
|
|
T1–T2 (< 94.1)
|
854/819
|
Ref.
| |
Ref.
| |
|
T3 (≥ 94.1)
|
401/436
|
0.87 (0.73, 1.04)
|
0.119
|
0.76 (0.63, 0.93)
|
0.007
|
|
Ischemic stroke
|
|
Tertiles
|
|
T1 (< 79.1)
|
360/363
|
Ref.
| |
Ref.
| |
|
T2 (79.1 to < 94.1)
|
372/340
|
1.10 (0.89, 1.35)
|
0.376
|
1.05 (0.83, 1.33)
|
0.672
|
|
T3 (≥ 94.1)
|
347/376
|
0.92 (0.74, 1.14)
|
0.444
|
0.78 (0.60, 0.99)
|
0.045
|
|
Categories
|
|
T1–T2 (< 94.1)
|
732/703
|
Ref.
| |
Ref.
| |
|
T3 (≥ 94.1)
|
347/376
|
0.87 (0.72, 1.06)
|
0.163
|
0.75 (0.61, 0.93)
|
0.009
|
|
Hemorrhagic stroke
|
|
Tertiles
|
|
T1 (< 79.1)
|
58/54
|
Ref.
| |
Ref.
| |
|
T2 (79.1 to < 94.1)
|
60/61
|
0.88 (0.50, 1.57)
|
0.673
|
0.76 (0.38, 1.55)
|
0.455
|
|
T3 (≥ 94.1)
|
53/56
|
0.85 (0.47, 1.54)
|
0.587
|
0.72 (0.35, 1.48)
|
0.371
|
|
Categories
|
|
T1–T2 (< 94.1)
|
118/115
|
Ref.
| |
Ref.
| |
|
T3 (≥ 94.1)
|
53/56
|
0.92 (0.57, 1.47)
|
0.718
|
0.85 (0.48, 1.50)
|
0.577
|
- a ORs of first stroke (total), first ischemic, and hemorrhagic stroke in relation to plasma selenium (tertiles) were analyzed using conditional logistic regression models. Model 1 is conditioned on the matching factors of age and sex; model 2 is conditioned on the matching factors of age and sex, as well as adjusted for BMI, baseline SBP, baseline DBP, smoking status, alcohol consumption, labour intensity, baseline total homocysteine, vitamin E, fasting glucose, estimated glomerular filtration rate (eGFR), anti-platelet drugs, lipoprotein-lowering drugs, glucose-lowering drugs, anti-hypertensive drugs, self-reported hypertension, self-reported atrial fibrillation, self-reported diabetes, and self-reported hyperlipidemia.
