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Table 1 Demographic characteristics of discovery and replication cohorts

From: A cross-cohort analysis of autosomal DNA methylation sex differences in the term placenta

 

Discovery

Replication

Female (n = 177)

Male (n = 164)

p value*

Female (n = 137)

Male (n = 156)

p value*

Gestational Age

 Weeks (mean (SD))

39.0 (± 1.1)

39.1 (± 0.9)

0.53

39.6 (± 1.1)

39.7 (± 1.0)

0.28

Condition

 Healthy term

100

100

0.02

114

125

0.10

 SGA

37

45

 

9

4

 

 LGA

40

19

 

13

24

 

PlaNET Ancestry§

 Coordinate 1 (mean (SD))

0.10 (± 0.25)

0.07 (± 0.23)

0.27

0.0009 (± 0. 0016)

0.0012 (± 0.0018)

0.000024

 Coordinate 2 (mean (SD))

0.11 (± 0.26)

0.05 (± 0.14)

0.37

0.0038 (± 0.0270)

0.0032 (± 0.0103)

0.011

 Coordinate 3 (mean (SD))

0.78 (± 0.36)

0.88 (± 0.27)

0.23

0.9951 (± 0.0279)

0.9956 (± 0.0111)

0.001

  1. SD refers to standard deviation; SGA and LGA refer to small (< 10th centile) and large (> 90th centile) birthweight for gestational age within each sex, as assigned by the original publications
  2. *p values represent male-female comparisons, from Wilcoxon rank-sum tests for continuous and Fisher’s exact test for categorical variables
  3. §PlaNET outputs of DNAme-based ethnicity/ancestry probability values range from 0 to 1 and sum to 1 for each sample. Coordinate 1 is associated with probability of African ancestry, coordinate 2 with East Asian ancestry, and coordinate 3 with European ancestry [40]
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Biology of Sex Differences

ISSN: 2042-6410

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