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Fig. 3 | Biology of Sex Differences

Fig. 3

From: A cross-cohort analysis of autosomal DNA methylation sex differences in the term placenta

Fig. 3

Principal components analysis of DNAme at the 162 significantly sex-differentially methylated CpGs. a Density plot of male (M, red curve) and female (F, yellow curve) samples along PC1 of the 162 sex-associated DMPs. b Scatterplot of PC1 versus PC2 of the discovery cohort; male (M) samples are plotted in red, and females (F) in yellow. c Significant associations between clinical variables and PC1 in a sex-stratified analyses. Linear regression R2 and p values are reported for each significant variable; a yellow arrow indicates significant association in females, and a red arrow indicates significant association in males. PC indicates principal component

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