Fig. 2

Scatterplots of sex-differentially methylated regions and probes in key genes. a Differentially methylated region spanning 5 CpGs in ZNF300 in chromosome 5; male samples are indicated in red, and females in orange; the CpG coordinates along chromosome 5 are indicated on the X axis, while DNA methylation β values for each sample are plotted along the Y axis. Gene tracks from the UCSC Genome Browser with the CpG locations are indicated. b A differentially methylated region in ZNF423; coordinates along chromosome 16 are indicated on the X axis. c A significantly differentially methylated CpG site in the gene body of SPON1; this site overlaps an estrogen receptor β binding site