Sex differences in soluble prorenin receptor in patients with type 2 diabetes

Table 4 Multiple regression analysis with eGFR

Predictors	Urine Renin Activity			Plasma sPRR			Urine sPRR
Predictors	β	t	P value	β	t	P value	β	t	P value
Model 1—constant	94.47	49.29	< 0.001	100.52	20.55	< 0.001	86.11	41.58	< 0.001
Model 2—constant	114.89	9.61	< 0.001	117.29	10.18	< 0.001	112.37	9.88	< 0.001
Type 2 diabetes	− 3.79	− 0.89	0.377	− 5.19	− 1.39	0.1673	− 2.76	− 0.74	0.462
Age	− 0.70	− 5.75	< 0.001	− 0.72	− 6.25	< 0.001	− 0.688	− 5.51	< 0.001
Sex	3.09	1.02	0.307	3.81	1.40	0.1640	3.73	1.31	0.190
Race	− 9.66	− 3.05	0.0026	− 11.67	− 4.01	< 0.001	− 11.89	− 4.01	< 0.001
Body weight (kg)	− 0.06	− 0.18	0.010	− 0.486	− 1.83	0.073	2.69	2.52	0.012
BMI	0.33	1.68	0.093	0.197	1.08	0.2829	0.17	0.92	0.359
DBP	0.137	0.90	0.371	0.154	1.06	0.2887	0.22	1.42	0.158
SBP	− 0.05	− 0.53	0.594	− 0.04	− 0.40	0.6877	− 0.09	− 0.92	0.359
Anti-hypertensives	− 1.18	− 1.96	0.052	− 1.751	− 3.254	0.001	− 2.10	− 3.94	< 0.001
Anti-diabetic medications	1.84	0.29	0.773	3.762	0.639	0.524	0.85	6.11	0.900

Urine Renin Activity: Model 1: P = 0.0038, R² = 3.9%; Model 2: P < 0.001, R² = 24.32%
Plasma sPRR: Model 1: P = 0.0058, R² = 3.4%; Model 2: P < 0.001, R² = 25.67%
Urine sPRR Model 1: P = 0.0357, R² = 3.4%; Model 2: P = 0.001, R² = 26.61%

ISSN: 2042-6410