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Table 2 Soluble PRR, renin, prorenin, AGT, and TGF-β1 in plasma and urine

From: Sex differences in soluble prorenin receptor in patients with type 2 diabetes

Variables Total participants Men Women
  Control Type 2 diabetes P value Control Type 2 diabetes P value Control Type 2 diabetes P value
Plasma
 sPRR (ng/mL) 16.5 (15.8–17) 19.2 (17–21)* 0.001 18 (16.5–19) 17 (16–20) 0.87 15 (14.8–16) † 20 (18–22)‡ 0.05
0.001
 Renin activity (ng Ang-I /mL/h) 3.2 (2.7–3.8) 12 (10–14)* 0.001 3.5 (2.5–4.5) 9.8 (6.4–13.3)† ‡ ** 0.001
0.001
**0.05
3.0 (2.3–3.7) 13 (11–15.6)† ‡ 0.001
0.001
Urine
 sPRR/uCr (ng/mg) 1.6 (1.3–1.8) 0.8 (0.6–1)* 0.001 1.8 (1.4–2.4) 0.6 (0.4–0.8)† ‡ 0.001
0.05
1.3 (1–1.7) 1.0 (0.75–1.3) † 0.001
 Renin activity (ng Ang-I /mL/h) 27 (21–33) 99 (77–120)* 0.001 27 (16.5–37.4) 125 (82–168)† ‡ ** 0.001
0.001
**0.05
27 (20–34) 84 (60–108)† ‡ 0.001
0.001
 Prorenin/uCr (ng/g) 141 (109–173) 302 (232–371)* 0.01 128 (91–165) 362 (215–508)† ‡ 0.01
0.05
153 (103–204) 273 (199–348) 0.01
 AGT/uCr (μg/g) 16 (13–19) 25 (17–32)* 0.02 15 (11–20) 30 (17–42)† ‡ 0.05
0.05
16 (12–20) 21 (11–20) 0.52
 TGF-β1/uCr (pg/mg) 18 (14–22) 31 (24–38)* 0.001 16 (11–21) 33 (20–45) 0.05 19 (13–25) 31 (23–39) 0.05
  1. Data are shown as mean (95% confident intervals). *Different from total participants’ control; Different from men control; Different from women control. **Different from women with type 2 diabetes