Table 1 GEE (generalized estimation equation) model with blood pressure, heart rate, or tail temperature as the dependent variable, and sex, vapor condition, and time as independent factors

 Sex

4.996

1

0.025

*

 Vapor condition

5.795

1

0.016

*

 Time

806.670

14

< 0.001

*

 Sex × vapor

3.086

1

0.079

 Sex × time

155.382

14

< 0.001

*

 Vapor × time

42.638

14

< 0.001

*

 Sex × vapor × time

96.417

14

< 0.001

*

 Sex

0.167

1

0.683

 Vapor condition

1.304

1

0.253

 Time

447.653

14

< 0.001

*

 Sex × vapor

0.003

1

0.955

 Sex × time

116.907

14

< 0.001

*

 Vapor × time

88.871

14

< 0.001

*

 Sex × vapor × time

62.33

14

< 0.001

*

 Sex

0.854

1

0.355

 Vapor condition

0.033

1

0.857

 Time

42.697

6

< 0.001

*

 Sex × vapor

0.195

1

0.659

 Sex × time

14.260

6

0.027

*

 Vapor × time

2.746

6

0.840

 Sex × vapor × time

6.353

6

0.385