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Table 3 Significant functions in the functional meta-analyses. The logarithm of the odds ratio (LOR), its confidence interval (LOR-CI), the adjusted p value, and the group in which the function was overexpressed are shown (W, women; M, men)

From: Hepatic steatosis and steatohepatitis: a functional meta-analysis of sex-based differences in transcriptomic studies

 

GO ID

Name

LOR

LOR-CI

Adj. p value

Group

Gene functional meta-analysis

GO:0001012

RNA polymerase II regulatory region DNA binding

0.132

[0.079, 0.185]

0.008

W

GO:1900165

Negative regulation of interleukin-6 secretion

-0.762

[-1.088, -0.437]

0.018

M

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

0.131

[0.073, 0.188]

0.02

W

GO:0017166

Vinculin binding

0.511

[0.271, 0.75]

0.035

W

GO:0071352

Cellular response to interleukin-2

0.467

[0.248, 0.687]

0.035

W

GO:0090177

Establishment of planar polarity involved in neural tube closure

-0.514

[-0.748, -0.279]

0.035

M

GO:0090178

Regulation of establishment of planar polarity involved in neural tube closure

-0.523

[-0.768, -0.279]

0.035

M

GO:1901215

Negative regulation of neuron death

0.116

[0.06, 0.171]

0.043

W

GO:0070669

Response to interleukin-2

0.446

[0.23, 0.662]

0.046

W

Pathway functional meta-analysis

GO:0098655

Cation transmembrane transport

0.194

[0.11, 0.279]

0.012

W

GO:0030001

Metal ion transport

0.141

[0.074, 0.208]

0.027

W

GO:1904062

Regulation of cation transmembrane transport

0.216

[0.119, 0.32]

0.027

W

GO:0098662

Inorganic cation transmembrane transport

0.186

[0.093, 0.278]

0.038

W