Fig. 3

Representation of results of the bioinformatics analysis. a UpSet plot showing the number of common results throughout individual studies in our functional gene analysis. Only the twenty most abundant interactions are shown. Horizontal bars indicate the number of significant elements in each study (premenopausal [orange] women and men [blue]). The vertical bars indicate the common elements in the sets, indicated with dots under each bar. The single points represent the number of unique elements in each group. Those vertical bars with dots of both colors beneath indicate significant amounts of molecular bases in men and women, in a contradictory way, in different studies. b Example of a forest plot from the meta-analysis. This representation allows us to observe the LOR and confidence interval of the GO terms in each study (horizontal bars) and the meta-analysis (diamond). c Example of a funnel plot from the meta-analysis. Dots in the white area indicate the absence of bias and heterogeneity