Fig. 1
From: Thyroid hormone: sex-dependent role in nervous system regulation and disease
Mechanism of TH intracellular action. The introduction of TH into the cell is mediated by transporters. T4 can be converted into T3 by the enzyme, DIO2. DIO1 is also involved in the conversion of T4 (not shown in the figure). T3 and T4 bind to the THRs mainly associated with RXR, and this binding leads to the conformational change of THRs followed by dissociation of corepressors and recruitment of coactivators. This leads to the expression of genes that are located downstream of TREs