Skip to main content

Table 2 Glia to neuron ratio (GNR) in various brain regions associated with oxidative stress-related CNS disorders

From: Neuroprotective and neurotoxic outcomes of androgens and estrogens in an oxidative stress environment

Brain region GNR Citations for GNR Associated disorders Citations for disorders
Cortex (monkey) 1:1 [108] Female bias: AD, MD, ANX
Male bias: PD, SZ, ASD
[109,110,111,112,113,114]
Cortex (human) 4:1 [115]
Cortex (rat) 1:1 [116]   
Striatum (mouse) 1:17 [117] Female bias: MD [110, 111, 113]
Male bias: PD, SZ, ASD
Basal ganglia (human) 1:2 [118] Female bias: MD, [110, 111, 113, 114]
Male bias: PD, SZ, ASD
Substantia nigra pars compacta (mouse) 1:9 [119] Female bias:— [110, 120]
Male bias: PD, SZ
Thalamus (human) 17:1 [121] Female bias: MD [111, 113, 122]
Male bias: PD, SZ
Hippocampus overall (mouse) 1:1 [117] Female bias: AD, MD, ANX,
Male bias: PD, SZ, ASD
[109,110,111,112,113,114]
CA1 (mouse) 1:2 [117]   
CA3 (mouse) 1:3 [117]
Locus coeruleus (human) 27:1 [123] Female bias: AD, MD [110,111,112, 124, 125]
Male bias: PD, ANX
Amygdala basolateral (rat) 1:7 [117, 126] Female bias: AD, MD, ANX, [110, 112, 114, 127]
Male bias: PD, ASD
Spinal cord (rat) 1:6 [128] Female bias:— [110]
Male bias: PD
Cerebellum (mouse)
Cerebellum (human)
1:1
1:4
[117]
[115]
Female bias:— [110, 114]
Male bias: PD, ASD
  1. AD Alzheimer’s disease, PD Parkinson’s disease, MD major depression, ANX anxiety disorders, SZ schizophrenia, ASD autism spectrum disorders