Fig. 8

The role of estrogen receptor in hormone-induced neurodegeneration. Estrogen receptor antagonist, ICI, did not prevent testosterone and 17β-estradiol’s detrimental effects after H₂O₂ exposure in N27 cells (a, b) and C6 cells (c, d). Results were determined by ANOVA followed by Fisher LSD post hoc test. Results are reported as mean + SEM. p < 0.05; *versus control, **versus H₂O₂. C, vehicle control; T, 100 nM testosterone; H, H₂O₂; HT, post-treatment T. E, 1 nM 17β-estradiol; HE, post-treatment E