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Table 3 Association of sphingolipids with age

From: Sex differences in the association of sphingolipids with age in Dutch and South-Asian Surinamese living in Amsterdam, the Netherlands

Sphingolipid (nMol/L) Dutch men (N = 174)   Dutch women (N = 176)   Interaction by sex SA Sur men (N = 154)   SA Sur women (N = 196)   Interaction by sex
  B (95% CI) P value B (95% CI) P value P value B (95% CI) P value B (95% CI) P value P value
Ceramides
 Cer(d18:1)
  Model 1 52 (27; 78) < 0.001 82 (62; 102) < 0.001 0.07 27 (0; 54) 0.05 33 (13; 53) 0.002 0.72
  Model 2 31 (2; 59) 0.03 76 (55; 98) < 0.001 0.05 33 (4; 61) 0.03 31 (10; 53) 0.005 0.73
 Cer(d18:2)
  Model 1 6.4 (1.6; 11.2) 0.009 16.7 (12.7; 20.7) < 0.001 0.001 6.9 (1.7; 12.2) 0.01 9.9 (5.6; 14.2) < 0.001 0.38
  Model 2 3.2 (− 2.1; 8.5) 0.23 15.92 (11.57; 20.26) < 0.001 0.001 8.3 (2.7; 14.0) 0.004 9.9 (5.4 14.52) < 0.001 0.37
 Cer(d18:0)           
  Model 1 7.9 (1.5; 14.2) 0.02 9.4 (3.1; 15.7) 0.004 0.73 5.0 (− 3.6; 13.6) 0.25 4.1 (− 2.8; 11.0) 0.24 0.87
  Model 2 2.2 (− 4.7; 9.1) 0.53 5.7 (− 1.0; 12.3) 0.09 0.55 6.6 (− 2.4; 15.7) 0.15 3.2 (− 4.2; 10.5) 0.40 0.70
 Cer(d16:1)           
  Model 1 3.2 (0.9; 5.5) 0.007 5.7 (3.9; 7.5) < 0.001 0.10 4.3 (1.9; 6.8) 0.001 3.6 (1.9; 5.3) < 0.001 0.62
  Model 2 1.1 (− 1.3; 3.6) 0.37 5.3 (3.4; 7.3) < 0.001 0.07 4.7 (2.1; 7.3) < 0.001 3.8 (1.9; 5.6) < 0.001 0.59
 Cer(d16:1)           
  Model 1 2.3 (0.8; 3.9) 0.003 4.0 (2.7; 5.2) < 0.001 0.10 2.0 (0.5; 3.4) 0.01 2.0 (0.9; 3.1) < 0.001 0.97
  Model 2 1.7 (− 0.0; 3.4) 0.06 4.1 (2.7; 5.4) < 0.001 0.10 2.4 (0.8; 4.0) 0.003 2.3 (1.1; 3.4) < 0.001 0.96
 Cer(d20:1)           
  Model 1 1.07 (0.33; 1.81) 0.005 0.86 (− 0.27; 1.99) 0.13 0.77 − 0.07 (− 1.01; 0.87) 0.88 0.75 (− 0.01; 1.51) 0.05 0.18
  Model 2 0.79 (− 0.04; 1.61) 0.06 0.88 (− 0.34; 2.11) 0.16 0.85 0.09 (− 0.91; 1.09) 0.86 0.71 (− 0.10; 1.53) 0.09 0.21
1-Deoxysphinganine
 Cer(m18:0)           
  Model 1 7.9 (1.5; 14.2) 0.02 9.4 (3.1; 15.7) 0.004 0.73 5.0 (− 3.6; 13.6) 0.25 4.1 (− 2.8; 11.0) 0.24 0.87
  Model 2 2.2 (− 4.7; 9.1) 0.53 5.7 (− 1.0; 12.3) 0.09 0.55 6.6 (− 2.4; 15.7) 0.15 3.2 (− 4.2; 10.5) 0.40 0.70
Glucosylceramides
 GlcCer(d18:1)           
  Model 1 21 (9; 33) 0.001 33 (21; 45) < 0.001 0.16 3 (− 10; 17) 0.64 4 (− 6; 14) 0.43 0.91
  Model 2 21 (8; 34) 0.002 40 (27; 52) < 0.001 0.17 6 (− 9; 20) 0.44 5 (− 6; 16) 0.38 0.52
 GlcCer(d18:2)           
  Model 1 4.1 (2.4; 5.7) < 0.001 6.9 (5.2; 8.7) < 0.001 0.02 1.4 (− 0.4; 3.2) 0.13 3.4 (1.7; 5.1) < 0.001 0.11
  Model 2 4.3 (2.4; 6.1) < 0.001 7.6 (5.7; 9.5) < 0.001 0.02 1.9 (− 0.0; 3.8) 0.06 3.7 (2.0; 5.5) < 0.001 0.10
Lactosylceramides
 LacCer(d18:1)           
  Model 1 0.3 (− 8.5; 9.2) 0.94 9.1 (0.5; 17.6) 0.04 0.16 − 7.9 (− 17.4; 2.1) 0.12 − 11.1 (− 18.7; − 3.6) 0.004 0.58
  Model 2 1.6 (− 8.4; 11.5) 0.64 12.7 (3.6; 21.8) 0.007 0.19 − 6.5 (− 17.1; 4.1) 0.23 − 11.2 (− 19.3; − 3.1) 0.007 0.58
 LacCer(d18:2)           
  Model 1 1.4 (0.1; 2.6) 0.03 4.6 (3.2; 5.9) < 0.001 0.001 − 0.1 (− 1.4; 1.1) 0.86 1.2 (0.0; 2.4) 0.04 0.12
  Model 2 1.4 (0.0; 2.8) 0.05 4.8 (3.4; 6.3) < 0.001 0.001 0.0 (− 1.3; 1.4) 0.94 1.2 (0.0; 2.5) 0.06 0.13
Globotriaosylceramides
 CTH(d18:1)           
  Model 1 2.3 (− 0.6; 5.1) 0.12 5.2 (1.8; 8.6) 0.003 0.20 − 0.4 (− 3.6; 2.7) 0.79 1.2 (− 1.5; 3.9) 0.39 0.44
  Model 2 3.6 (0.4; 6.8) 0.03 7.2 (3.7; 10.8) < 0.001 0.24 1.0 (− 2.3; 4.4) 0.13 2.4 (− 0.5; 5.2) 0.10 0.33
 CTH(d18:2)           
  Model 1 1.0 (0.4; 1.6) 0.002 1.8 (1.0; 2.6) < 0.001 0.14 0.2 (− 0.5; 0.9) 0.61 1.2 (0.4; 2.0) 0.003 0.07
  Model 2 1.1 (0.4; 1.8) 0.002 2.1 (1.2; 2.9) < 0.001 0.18 0.4 (− 0.4; 1.2) 0.29 1.3 (0.4; 2.2) 0.003 0.08
  1. Model 1 shows the unadjusted increase in sphingolipid concentrations by age, while model 2 was adjusted for BMI and waist circumference