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Table 3 Association of sphingolipids with age

From: Sex differences in the association of sphingolipids with age in Dutch and South-Asian Surinamese living in Amsterdam, the Netherlands

Sphingolipid (nMol/L)

Dutch men (N = 174)

 

Dutch women (N = 176)

 

Interaction by sex

SA Sur men (N = 154)

 

SA Sur women (N = 196)

 

Interaction by sex

 

B (95% CI)

P value

B (95% CI)

P value

P value

B (95% CI)

P value

B (95% CI)

P value

P value

Ceramides

 Cer(d18:1)

  Model 1

52 (27; 78)

< 0.001

82 (62; 102)

< 0.001

0.07

27 (0; 54)

0.05

33 (13; 53)

0.002

0.72

  Model 2

31 (2; 59)

0.03

76 (55; 98)

< 0.001

0.05

33 (4; 61)

0.03

31 (10; 53)

0.005

0.73

 Cer(d18:2)

  Model 1

6.4 (1.6; 11.2)

0.009

16.7 (12.7; 20.7)

< 0.001

0.001

6.9 (1.7; 12.2)

0.01

9.9 (5.6; 14.2)

< 0.001

0.38

  Model 2

3.2 (− 2.1; 8.5)

0.23

15.92 (11.57; 20.26)

< 0.001

0.001

8.3 (2.7; 14.0)

0.004

9.9 (5.4 14.52)

< 0.001

0.37

 Cer(d18:0)

          

  Model 1

7.9 (1.5; 14.2)

0.02

9.4 (3.1; 15.7)

0.004

0.73

5.0 (− 3.6; 13.6)

0.25

4.1 (− 2.8; 11.0)

0.24

0.87

  Model 2

2.2 (− 4.7; 9.1)

0.53

5.7 (− 1.0; 12.3)

0.09

0.55

6.6 (− 2.4; 15.7)

0.15

3.2 (− 4.2; 10.5)

0.40

0.70

 Cer(d16:1)

          

  Model 1

3.2 (0.9; 5.5)

0.007

5.7 (3.9; 7.5)

< 0.001

0.10

4.3 (1.9; 6.8)

0.001

3.6 (1.9; 5.3)

< 0.001

0.62

  Model 2

1.1 (− 1.3; 3.6)

0.37

5.3 (3.4; 7.3)

< 0.001

0.07

4.7 (2.1; 7.3)

< 0.001

3.8 (1.9; 5.6)

< 0.001

0.59

 Cer(d16:1)

          

  Model 1

2.3 (0.8; 3.9)

0.003

4.0 (2.7; 5.2)

< 0.001

0.10

2.0 (0.5; 3.4)

0.01

2.0 (0.9; 3.1)

< 0.001

0.97

  Model 2

1.7 (− 0.0; 3.4)

0.06

4.1 (2.7; 5.4)

< 0.001

0.10

2.4 (0.8; 4.0)

0.003

2.3 (1.1; 3.4)

< 0.001

0.96

 Cer(d20:1)

          

  Model 1

1.07 (0.33; 1.81)

0.005

0.86 (− 0.27; 1.99)

0.13

0.77

− 0.07 (− 1.01; 0.87)

0.88

0.75 (− 0.01; 1.51)

0.05

0.18

  Model 2

0.79 (− 0.04; 1.61)

0.06

0.88 (− 0.34; 2.11)

0.16

0.85

0.09 (− 0.91; 1.09)

0.86

0.71 (− 0.10; 1.53)

0.09

0.21

1-Deoxysphinganine

 Cer(m18:0)

          

  Model 1

7.9 (1.5; 14.2)

0.02

9.4 (3.1; 15.7)

0.004

0.73

5.0 (− 3.6; 13.6)

0.25

4.1 (− 2.8; 11.0)

0.24

0.87

  Model 2

2.2 (− 4.7; 9.1)

0.53

5.7 (− 1.0; 12.3)

0.09

0.55

6.6 (− 2.4; 15.7)

0.15

3.2 (− 4.2; 10.5)

0.40

0.70

Glucosylceramides

 GlcCer(d18:1)

          

  Model 1

21 (9; 33)

0.001

33 (21; 45)

< 0.001

0.16

3 (− 10; 17)

0.64

4 (− 6; 14)

0.43

0.91

  Model 2

21 (8; 34)

0.002

40 (27; 52)

< 0.001

0.17

6 (− 9; 20)

0.44

5 (− 6; 16)

0.38

0.52

 GlcCer(d18:2)

          

  Model 1

4.1 (2.4; 5.7)

< 0.001

6.9 (5.2; 8.7)

< 0.001

0.02

1.4 (− 0.4; 3.2)

0.13

3.4 (1.7; 5.1)

< 0.001

0.11

  Model 2

4.3 (2.4; 6.1)

< 0.001

7.6 (5.7; 9.5)

< 0.001

0.02

1.9 (− 0.0; 3.8)

0.06

3.7 (2.0; 5.5)

< 0.001

0.10

Lactosylceramides

 LacCer(d18:1)

          

  Model 1

0.3 (− 8.5; 9.2)

0.94

9.1 (0.5; 17.6)

0.04

0.16

− 7.9 (− 17.4; 2.1)

0.12

− 11.1 (− 18.7; − 3.6)

0.004

0.58

  Model 2

1.6 (− 8.4; 11.5)

0.64

12.7 (3.6; 21.8)

0.007

0.19

− 6.5 (− 17.1; 4.1)

0.23

− 11.2 (− 19.3; − 3.1)

0.007

0.58

 LacCer(d18:2)

          

  Model 1

1.4 (0.1; 2.6)

0.03

4.6 (3.2; 5.9)

< 0.001

0.001

− 0.1 (− 1.4; 1.1)

0.86

1.2 (0.0; 2.4)

0.04

0.12

  Model 2

1.4 (0.0; 2.8)

0.05

4.8 (3.4; 6.3)

< 0.001

0.001

0.0 (− 1.3; 1.4)

0.94

1.2 (0.0; 2.5)

0.06

0.13

Globotriaosylceramides

 CTH(d18:1)

          

  Model 1

2.3 (− 0.6; 5.1)

0.12

5.2 (1.8; 8.6)

0.003

0.20

− 0.4 (− 3.6; 2.7)

0.79

1.2 (− 1.5; 3.9)

0.39

0.44

  Model 2

3.6 (0.4; 6.8)

0.03

7.2 (3.7; 10.8)

< 0.001

0.24

1.0 (− 2.3; 4.4)

0.13

2.4 (− 0.5; 5.2)

0.10

0.33

 CTH(d18:2)

          

  Model 1

1.0 (0.4; 1.6)

0.002

1.8 (1.0; 2.6)

< 0.001

0.14

0.2 (− 0.5; 0.9)

0.61

1.2 (0.4; 2.0)

0.003

0.07

  Model 2

1.1 (0.4; 1.8)

0.002

2.1 (1.2; 2.9)

< 0.001

0.18

0.4 (− 0.4; 1.2)

0.29

1.3 (0.4; 2.2)

0.003

0.08

  1. Model 1 shows the unadjusted increase in sphingolipid concentrations by age, while model 2 was adjusted for BMI and waist circumference