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Table 2 Baseline sphingolipid concentrations in men compared to women, stratified by age group

From: Sex differences in the association of sphingolipids with age in Dutch and South-Asian Surinamese living in Amsterdam, the Netherlands

Cer(d18:1) (nmol/L)
   Men Women Age-adjusted difference   Age-, BMI-, and waist-adjusted difference  
   Mean (SD) Mean (SD) B (95% CI) P value B (95% CI) P value
Dutch 18–39 years (N = 59/68) 8369 (2095) 7572 (1371) – 707 (– 1327; – 86) 0.03 – 432 (– 1081; 217) 0.19
40–55 years (N = 57/55) 9562 (2413) 8957 (2417) – 744 (– 1621; 133) 0.10 – 386 (– 1346; 574) 0.43
56–70 years (N = 58/53) 9926 (2435) 10244 (1874) 324 (– 509; 1157) 0.44 512 (– 464; 1489) 0.30
South-Asian Surinamese 18–39 years (N = 53/63) 8311 (2186) 7689 (1712) – 625 (– 1330; 80) 0.08 – 259 (– 1076; 558) 0.53
40–55 years (N = 75/84) 8964 (2006) 8631 (2106) – 407 (– 1047; 232) 0.21 – 539 (– 1274; 196) 0.15
56–70 years (N = 26/49) 8476 (2364) 8581 (1695) 170 (– 790; 1130) 0.73 105 (– 982; 1192) 0.85
Cer(d18:2) (nmol/L)
   Men Women Age-adjusted difference   Age-, BMI-, and waist-adjusted difference  
   Mean (SD) Mean (SD) B (95% CI) P value B (95% CI) P value
Dutch 18–39 years (N = 59/68) 1256 (423) 1113 (250) – 123 (– 245; – 2) 0.05 – 87 (– 215; 41) 0.18
40–55 years (N = 57/55) 1397 (427) 1364 (448) – 55 (– 216; 106) 0.50 2 (– 175; 179) 0.98
56–70 years (N = 58/53) 1448 (438) 1653 (461) 208 (37; 379) 0.02 204 (3; 406) 0.05
South-Asian Surinamese 18–39 years (N = 53/63) 1222 (405) 1221 (350) – 1 (– 138; 136) 0.99 94 (– 64; 252) 0.24
40–55 years (N = 75/84) 1351 (424) 1386 (449) 23 (– 114; 160) 0.74 – 37 (– 194; 119) 0.64
56–70 years (N = 26/49) 1374 (448) 1551 (358) 181 (– 13; 374) 0.07 153 (– 66; 372) 0.17
Cer(d18:0) (nmol/L)
   Men Women Age-adjusted difference   Age-, BMI-, and waist-adjusted difference  
   Mean (SD) Mean (SD) B (95% CI) P value B (95% CI) P value
Dutch 18–39 years (N = 59/68) 2081 (610) 2185 (673) 126 (– 105; 357) 0.28 260 (22; 498) 0.03
40–55 years (N = 57/55) 2240 (551) 2287 (568) 18 (– 187; 222) 0.87 84 (– 138; 305) 0.46
56–70 years (N = 58/53) 2305 (552) 2491 (504) – 13 (– 37; 373) 0.09 29 (59; 525) 0.01
South-Asian Surinamese 18–39 years (N = 53/63) 2264 (583) 2229 (573) – 36 (– 249; 178) 0.74 – 96 (– 340; 149) 0.44
40–55 years (N = 75/84) 2415 (723) 2480 (679) 54 (– 167; 274) 0.63 58 (– 194; 310) 0.65
56–70 years (N = 26/49) 2316 (754) 2285 (601) – 14 (– 338; 311) 0.93 – 119 (– 491; 252) 0.52
Cer(d16:1) (nmol/L)
   Men Women Age-adjusted difference   Age-, BMI-, and waist-adjusted difference  
   Mean (SD) Mean (SD) B (95% CI) P value B (95% CI) P value
Dutch 18–39 years (N = 59/68) 449 (192) 418 (143) – 25 (– 85; 35) 0.40 3 (– 60; 65) 0.93
40–55 years (N = 57/55) 537 (222) 476 (162) – 72 (– 143; – 2) 0.05 – 63 (– 141; 15) 0.11
56–70 years (N = 58/53) 541 (206) 601 (219) 64 (– 17; 145) 0.12 72 (– 23; 166) 0.14
South-Asian Surinamese 18–39 years (N = 53/63) 422 (208) 407 (156) – 15 (– 81; 50) 0.64 23 (– 53; 99) 0.55
40–55 years (N = 75/84) 466 (167) 457 (163) – 13 (– 65; 39) 0.62 – 34 (– 93; 26) 0.27
56–70 years (N = 26/49) 536 (257) 529 (166) 9.0 (– 86; 104) 0.85 – 8 (– 115; 100) 0.89
Cer(d17:1) (nmol/L)
   Men Women Age-adjusted difference   Age-, BMI-, and waist-adjusted difference  
   Mean (SD) Mean (SD) B (95% CI) P value B (95% CI) P value
Dutch 18–38 years (N = 59/68) 369 (109) 343 (102) – 19 (– 57; 18) 0.30 – 16 (– 57; 25) 0.44
40–55 years (N = 57/55) 430 (135) 394 (122) – 42 (– 89; 6) 0.08 – 39 (– 91; 14) 0.15
56–70 years (N = 58/53) 438 (165) 475 (132) 37 (– 21; 94) 0.21 33 (– 35; 101) 0.34
South-Asian Surinamese 18–39 years (N = 53/63) 307 (115) 296 (89) – 11 (– 48; 26) 0.56 6 (– 38; 49) 0.80
40–55 years (N = 75/84) 333 (112) 324 (114) – 14 (– 49; 22) 0.45 – 33 (– 73; 7) 0.11
56–70 years (N = 26/49) 347 (145) 356 (93) 17 (– 38; 72) 0.53 2 (– 58; 61) 0.96
Cer(d20:1) (nmol/L)
   Men Women Age-adjusted difference   Age-, BMI-, and waist-adjusted difference  
   Mean (SD) Mean (SD) B (95% CI) P value B (95% CI) P value
Dutch 18–39 years (N = 59/68) 186 (62) 192 (155) 13 (– 30; 56) 0.55 17 (– 30; 64) 0.47
40–55 years (N = 57/55) 211 (67) 189 (65) – 26 (– 50; – 2) 0.03 – 23 (– 50; 4) 0.09
56–70 years (N = 58/53) 218 (69) 207 (55) – 10 (– 34; 14) 0.40 – 1 (– 29; 27) 0.93
South-Asian Surinamese 18–39 years (N = 53/63) 189 (73) 155 (48) – 34 (– 56; – 12) 0.003 – 28 (-54; – 1) 0.04
40–55 years (N = 75/84) 201 (80) 179 (82) – 23 (49; 21) 0.07 – 31 (– 59; – 2) 0.04
56–70 years (N = 26/49) 165 (50) 178 (71) 10 (– 22; 41) 0.55 11 (– 25; 47) 0.55
Cer(m18:0) (nmol/L)
   Men Women Age-adjusted difference   Age-, BMI-, and waist-adjusted difference  
   Mean (SD) Mean (SD) B (95% CI) P value B (95% CI) P value
Dutch 18–39 years (N = 59/68) 31 (12) 26 (8) – 5 (– 9; – 2) 0.005 – 3 (– 6; 1) 0.14
40–55 years (N = 57/55) 33 (12) 29 (11) – 4 (– 9;0) 0.05 – 2 (– 7; 3) 0.41
56–70 years (N = 58/53) 33 (11) 31 (11) – 2 (– 6; 2) 0.27 2 (– 3; 6) 0.52
South-Asian Surinamese 18–39 years (N = 53/63) 33 (14) 26 (11) – 7 (– 12; – 3) 0.003 – 5 (– 11; 0) 0.05
40–55 years (N = 75/84) 35 (16) 30 (12) – 5 (– 10; – 1) 0.02 – 4 (– 9; 1) 0.08
56–70 years (N = 26/49) 36 (12) 31 (14) – 5 (– 11; 2) 0.17 – 5 (– 12; 3) 0.21
GlcCer(d18:1) (nmol/L)
   Men Women Age-adjusted difference   Age-, BMI-, and waist-adjusted difference  
   Mean (SD) Mean (SD) B (95% CI) P value B (95% CI) P value
Dutch 18–39 years (N = 59/68) 4265 (1073) 3899 (990) – 300 (– 665; 64) 0.11 – 228 (– 624; 169) 0.26
40–55 years (N = 57/55) 4481 (1045) 4353 (964) – 153 (– 531; 224) 0.42 – 254 (– 682; 173) 0.24
56–70 years (N = 58/53) 4870 (1108) 4963 (1463) 132 (– 355; 619) 0.59 17 (– 534; 569) 0.95
South-Asian Surinamese 18–39 years (N = 53/63) 3878 (932) 3963 (859) 84 (– 244; 413) 0.61 138 (– 251; 526) 0.48
40–55 years (N = 75/84) 3970 (1041) 4198 (1044) 229 (– 100; 559) 0.17 171 (– 209; 550) 0.38
56–70 years (N = 26/49) 3873 (1366) 3953 (878) 157 (– 361; 676) 0.55 215 (– 362; 791) 0.46
GlcCer(d18:2) (nmol/L)
   Men Women Age-adjusted difference   Age-, BMI-, and waist-adjusted difference  
   Mean (SD) Mean (SD) B (95% CI) P value B (95% CI) P value
Dutch 18–39 years (N = 59/68) 528 (147) 507 (124) – 13 (– 61; 35) 0.59 – 8 (– 60; 45) 0.78
40–55 years (N = 57/55) 558 (138) 611 (159) 27 (– 28; 82) 0.33 15 (– 47; 77) 0.47
56–70 years (N = 58/53) 652 (160) 734 (216) 86 (15; 158) 0.02 70 (– 13; 152) 0.10
South-Asian Surinamese 18–39 years (N = 53/63) 483 (126) 550 (122) 68 (22; 113) 0.004 73 (19; 127) 0.009
40–55 years (N = 75/84) 506 (142) 614 (185) 106 (54; 159) < 0.001 86 (26; 146) 0.005
56–70 years (N = 26/49) 526 (175) 648 (137) 136 (64; 209) < 0.001 144 (64; 224) 0.001
LacCer(d18:1) (nmol/L)
   Men Women Age-adjusted difference   Age-, BMI-, and waist-adjusted difference  
   Mean (SD) Mean (SD) B (95% CI) P value B (95% CI) P value
Dutch 18–39 years (N = 59/68) 3458 (857) 3311 (732) – 132 (– 418; 152) 0.36 – 120 (– 431; 191) 0.45
40–55 years (N = 57/55) 3372 (765) 3533 (740) 169 (– 116; 454) 0.24 114 (– 207; 435) 0.48
56–70 years (N = 58/53) 3457 (752) 3583 (948) 149 (– 174; 471) 0.36 0 (– 360; 360) 1.00
South-Asian Surinamese 18–39 years (N = 53/63) 3115 (765) 3308 (716) 193 (– 81; 467) 0.17 273 (– 50; 595) 0.10
40–55 years (N = 75/84) 2970 (727) 3238 (706) 286 (61; 511) 0.01 287 (28; 546) 0.03
56–70 years (N = 26/49) 2874 (935) 2889 (642) 19 (– 355; 392) 0.92 – 13 (– 433; 407) 0.95
LacCer(d18:2) (nmol/L)
   Men Women Age-adjusted difference   Age-, BMI-, and waist-adjusted difference  
   Mean (SD) Mean (SD) B (95% CI) P value B (95% CI) P value
Dutch 18–39 years (N = 59/68) 452 (117) 438 (98) – 10 (– 48; 28) 0.61 – 4 (– 46; 38) 0.86
40–55 years (N = 57/55) 461 (106) 526 (125) 61 (18; 105) 0.006 55 (7; 103) 0.03
56–70 years (N = 58/53) 492 (112) 584 (161) 95 (43; 147) < 0.001 80 (21; 140) 0.009
South-Asian Surinamese 18–39 years (N = 53/63) 395 (97) 458 (106) 66 (25; 100) 0.001 78 (34; 123) 0.001
40–55 years (N = 75/84) 386 (97) 491 (110) 104 (71; 137) < 0.001 100 (62; 138) < 0.001
56–70 years (N = 26/49) 396 (108) 495 (110) 102 (48; 156) < 0.001 101 (41; 161) 0.001
CTH(d18:1) (nmol/L)
   Men Women Age-adjusted difference   Age-, BMI-, and waist-adjusted difference  
   Mean (SD) Mean (SD) B (95% CI) P value B (95% CI) P value
Dutch 18–39 years (N = 59/68) 1004 (270) 1053 (306) 62 (– 41; 166) 0.23 66 (– 46; 178) 0.25
40–55 years (N = 57/55) 1023 (239) 1100 (263) 78 (– 17; 173) 0.11 38 (– 69; 145) 0.48
56–70 years (N = 58/53) 1067 (259) 1218 (385) 160 (37; 283) 0.01 89 (– 47; 226) 0.20
South-Asian Surinamese 18–39 years (N = 53/63) 950 (258) 1084 (244) 133 (40; 226) 0.005 117 (7; 228) 0.04
40–55 years (N = 75/84) 940 (247) 1110 (244) 170 (93; 248) < 0.001 138 (51; 225) 0.002
56–70 years (N = 26/49) 958 (241) 1109 (265) 164 (38; 290) 0.01 164 (32; 297) 0.02
CTH(d18.2) (nmol/L)
   Men Women Age-adjusted difference   Age-, BMI-, and waist-adjusted difference  
   Mean (SD) Mean (SD) B (95% CI) P value B (95% CI) P value
Dutch 18–39 years (N = 59/68) 204 (53) 234 (67) 318 (10; 54) 0.005 35 (11; 59) 0.005
40–55 years (N = 57/55) 215 (57) 262 (76) 46 (21; 71) < 0.001 39 (11; 67) 0.008
56–70 years (N = 58/53) 235 (57) 292 (90) 59 (31; 87) < 0.001 42 (10; 75) 0.01
South-Asian Surinamese 18–39 years (N = 53/63) 208 (53) 274 (71) 66 (46; 89) < 0.001 64 (36; 91) < 0.001
40–55 years (N = 75/84) 206 (61) 285 (69) 79 (58; 99) < 0.001 69 (45; 92) < 0.001
56–70 years (N = 26/49) 223 (53) 318 (87) 99 (61; 137) < 0.001 100 (57; 143) < 0.001