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Table 1 List of the proteins differentially expressed in the secretome of female and male ECs identified by LC-MSE

From: Sex-dependent differences in the secretome of human endothelial cells

Accession Description Peptide count/unique peptides Confidence score ANOVA (p) Max. fold change
Higher secretion by female cells
 P00352 Retinal dehydrogenase 1, ALDH1A1 9/9 66.77 5.83E−09 1.80
 P52209 6-Phosphogluconate dehydrogenase decarboxylating, PGD 3/3 18.43 3.74E−06 1.39
 P55072 Transitional endoplasmic reticulum ATPase, VCP 17/17 120.47 8.45E−07 1.31
Higher secretion by male cells
 O00469 Procollagen-lysine_2-oxoglutarate 5-dioxygenase 2, PLOD2 3/3 16.84 1.24E−05 1.58
 O60814 Histone H2B type 1-K, HIST1H2BK 3/3 21.68 1.20E−06 1.32
 P03956 Interstitial collagenase MMP1 15/15 114.51 1.41E−08 2.84
 P04083 Annexin A1, ANXA1 6/6 39.36 1.95E−06 1.25
 P07339 Cathepsin D, CTSD 3/3 18.87 6.45E−05 1.34
 P07355 Annexin A2, ANXA2 17/17 137.10 2.19E−06 1.25
 P08758 Annexin A5, ANXA5 6/6 40.18 1.08E−06 1.41
 P11021 78 kDa glucose-regulated protein, HSPA5 11/9 75.79 2.72E−06 1.20
 P14625 Endoplasmin, HSP90B1 6/5 36.50 3.11E−05 1.25
 P21810 Biglycan, BGN 13/13 86.33 2.20E−07 1.67
 P26022 Pentraxin-related protein PTX3 9/9 67.95 4.35E−06 2.32
 P27797 Calreticulin, CALR 8/8 50.99 5.28E−05 1.31
 P30101 Protein disulfide-isomerase A3, PDIA3 6/6 38.64 2.88E−05 1.32
 P34932 Heat shock 70 kDa protein 4, HSPA4 2/2 10.64 0.000344 1.20
 P62158 Calmodulin CALM3 5/5 51.14 2.62E−08 1.30
 P80723 Brain acid soluble protein 1, BASP1 2/2 11.70 2.48E−06 1.48
 Q01995 Transgelin, TAGLN 2/2 12.26 0.000132 1.39
 Q05639 Elongation factor 1-alpha 2, EEF1A2 6/2 36.12 0.002882 1.36
 Q12841 Follistatin-related protein 1, FSTL1 3/3 17.39 1.53E−05 1.26
 Q16270 Insulin-like growth factor-binding protein 7, IGFBP7 12/12 96.80 1.43E−07 1.37