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Table 1 Demographic and clinical characteristics of TARGET-OS and SEER-OS cases

From: Sex differences in expression of immune elements emerge in children, young adults and mice with osteosarcoma

  TARGET-OS SEER-OS
Total Females Males X2 p value Total Females Males X2 p value
N (%) N (%) N (%) N (%) N (%) N (%)
Sex
Male 50 (57.5)   50 (57.5)   1635 (55.6)   1635 (55.6)  
Female 37 (42.5) 37 (42.5)    1305 (44.4) 1305 (44.4)   
Age at diagnosis (years)
0- < 10 10 (11.5) 6 (16.2) 4 (8.0) 0.06 348 (11.8) 176 (13.5) 172 (10.5) 0.03
10- < 20 67 (77.0) 30 (81.1) 37 (74.0)   1675 (57.0) 718 (55.0) 957 (58.5)  
20- < 40 10 (11.5) 1 (2.7) 9 (18.0)   917 (31.2) 411 (31.5) 506 (31.0)  
Race/ethnicity
White 47 (65.3) 15 (46.9) 32 (80.0) 0.02 1354 (46.7) 623 (48.3) 731 (45.4) 0.20
Hispanic 11 (15.3) 9 (28.1) 2 (5.0)   857 (29.5) 359 (27.8) 498 (30.9)  
Black 7 (9.7) 4 (12.5) 3 (7.5)   459 (15.8) 211 (16.4) 248 (15.4)  
API 7 (9.7) 4 (12.5) 3 (7.5)   232 (8.0) 97 (7.5) 135 (8.4)  
  Missing 15 5 10   38 15 23  
TARGET year of diagnosis
1997-2005 34 (41.0) 12 (32.4) 22 (47.8) 0.18 - - -  
2006-2014 49 (59.0) 25 (67.6) 24 (52.2)   - - -  
  Missing 4 0 4      
SEER year of diagnosis
2000-2005 - - -   849 (28.9) 378 (29.0) 471 (28.8) 0.49
2006-2010 - - -   1025 (34.9) 468 (35.9) 557 (34.1)  
2011-2016 - - -   1066 (36.3) 459 (35.2) 607 (37.1)  
Primary site
Upper limb 6 (6.9) 4 (10.8) 2 (4.0) 0.35 397 (13.5) 166 (12.7) 231 (14.1) 0.04
Lower limb 79 (90.8) 33 (89.2) 46 (92.0)   2081 (70.8) 910 (69.7) 1171 (71.6)  
Other 2 (2.3) 0 (0.0) 2 (4.0)   462 (15.7) 229 (17.6) 233 (14.3)  
TARGET metastasis at diagnosis
Non-metastatic 65 (74.7) 25 (67.6) 40 (80.0) 0.22 - - -  
Metastatic 22 (25.3) 12 (32.4) 10 (20.0)   - - -  
SEER stage of disease
Local - - -   969 (36.2) 459 (38.6) 510 (34.3) 0.02
Regional - - -   1136 (42.5) 500 (42.1) 636 (42.8)  
Distant - - -   569 (21.3) 229 (19.3) 340 (22.9)  
  Missing      266 117 109  
Vital status
Alive 58 (68.2) 24 (64.9) 34 (70.8) 0.64 1971 (67.0) 921 (70.6) 1050 (64.2) 0.0003
Deceased 27 (31.8) 13 (35.1) 14 (29.2)   969 (33.0) 384 (29.4) 585 (35.8)  
  Missing 2 0 2   0 0 0