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Fig. 4 | Biology of Sex Differences

Fig. 4

From: Investigation of interleukin-2-mediated changes in blood pressure, fetal growth restriction, and innate immune activation in normal pregnant rats and in a preclinical rat model of preeclampsia

Fig. 4

a Placental preproendothelin expression in NP (n = 3), RUPP (n = 3), RUPP + LD IL-2 (n = 3), RUPP + MD IL-2 (n = 3), and RUPP + HD IL-2 (n = 3). Placental preproendothelin (PPET) was elevated in RUPP compared to NP rats. There was a significant reduction in placental PPET between RUPP + HD IL-2 and RUPP rats. b Renal cortex preproendothelin expression in NP (n = 3), RUPP (n = 3), RUPP + LD IL-2 (n = 3), RUPP + MD IL-2 (n = 3), and RUPP + HD IL-2 (n = 3). Renal cortex PPET is elevated in RUPP vs. NP rats. All doses of IL-2 reduced PPET expression in comparison to RUPP rats. Statistical differences were achieved using one-way ANOVA with Bonferroni post hoc analysis,*p < 0.05 vs NP control, +p < 0.05 vs. RUPP control, αp < 0.05 RUPP + LD IL-2 vs RUPP + HD IL-2

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