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Fig. 3 | Biology of Sex Differences

Fig. 3

From: Investigation of interleukin-2-mediated changes in blood pressure, fetal growth restriction, and innate immune activation in normal pregnant rats and in a preclinical rat model of preeclampsia

Fig. 3

a Circulating total and activated NK cells in NP (n = 12), RUPP (n = 4), RUPP + LD IL-2 (n = 6), RUPP + MD IL-2 (n = 3), RUPP + HD IL-2 (n = 5), NP + basiliximab (n = 7), and RUPP + basiliximab (n = 8). Circulating total and activated NK cells were elevated in RUPP vs NP rats. All doses of IL-2 administered to RUPP rats decreased circulating NK cells in comparison to RUPP rats. Basiliximab increased circulating activated NK cells in NP rats, while it reduced circulating activated NK cells in RUPP rats. b Placental total and activated NK cells in NP (n = 10), RUPP (n = 4), RUPP + LD IL-2 (n = 6), RUPP + MD IL-2 (n = 5), RUPP + HD IL-2 (n = 5), NP + basiliximab (n = 7), and RUPP + basiliximab (n = 7). Placental NK cells were elevated in RUPP vs NP rats. In addition, total placental NK cells were elevated with all doses of IL-2 in RUPP rats; however, activated NK cells were significantly reduced with IL-2 in RUPPs. RUPP + basiliximab treatment reduced placental total NK cells compared to RUPP rats. Statistical differences were achieved using two-way ANOVA with Bonferroni post hoc analysis, *p < 0.05 vs. NP control, +p < 0.05 vs. RUPP control, αp < 0.05 (NP + MD Il-2 vs. RUPP + MD IL-2)

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Biology of Sex Differences

ISSN: 2042-6410

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