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Table 2 Significant gene ontology terms enriched in the identified miRNAs differentially expressed in females vs. males

From: MicroRNA profiling of the pig periaqueductal grey (PAG) region reveals candidates potentially related to sex-dependent differences

GO term Number of genes Examples of genes Number of miRNAs Examples of miRNAs p value
Response to stress (GO:0006950) 1191 TERF2, POLR2B, VPS4A, VAPB, ARPC5, NDUFS2, B2M, TAOK3, E2F7, PELI1; 27 let-7b-5p, miR-126-3p, miR-138-5p, miR-140-3p, miR-142-5p; < 1e-325
Enzyme regulator activity (GO:0030234) 376 ARHGAP1, TBC1D20, TAOK3, TRIB3, RGS17, PFN1, ANP32E, PRLR, PKIA; 19 miR-146a-5p, miR-148a-3p, miR-28-3p, miR-34c-5p, miR-92b-3p; < 1e-325
Immune system process (GO:0002376) 742 ARPC5, B2M, PELI1, TRIB3, BRK1, IRS2, CCL2, ADAM9, ACTB; 26 miR-126-3p, miR-138-5p, miR-140-3p, miR-142-5p, miR-146a-5p; < 1e-325
Catabolic process (GO:0009056) 1146 RNF41, VPS4A, ABCD4, ERLIN1, YTHDC2, PPP1CA, RAB2B, RPA1; 26 miR-142-5p, miR-146a-5p, miR-181a-5p, miR-181b-5p, miR-185-5p; < 1e-325
Generation of precursor metabolites and energy (GO:0006091) 163 NDUFS2, PPP1CA, FASN, PRKCA, PYGL, PFKP, COX8A, ACOX1; 14 let-7b-5p, let-7i-5p, miR-181b-5p, miR-185-5p, miR-27b-3p; 1.11e-16
Transcription factor binding (GO:0008134) 233 FHL2, TRIP6, ACTB, NACA, TCF3, HIPK2, STAT3, HOXA7, PAX6; 16 miR-181b-5p, miR-27b-3p, miR-30e-5p, miR-532-5p; 4.10e-15
  1. Upregulated miRNAs are in bold