Table 2 Significant gene ontology terms enriched in the identified miRNAs differentially expressed in females vs. males

Response to stress (GO:0006950)

1191

TERF2, POLR2B, VPS4A, VAPB, ARPC5, NDUFS2, B2M, TAOK3, E2F7, PELI1;

27

let-7b-5p, miR-126-3p, miR-138-5p, miR-140-3p, miR-142-5p;

< 1e-325

Enzyme regulator activity (GO:0030234)

376

ARHGAP1, TBC1D20, TAOK3, TRIB3, RGS17, PFN1, ANP32E, PRLR, PKIA;

19

miR-146a-5p, miR-148a-3p, miR-28-3p, miR-34c-5p, miR-92b-3p;

< 1e-325

Immune system process (GO:0002376)

742

ARPC5, B2M, PELI1, TRIB3, BRK1, IRS2, CCL2, ADAM9, ACTB;

26

miR-126-3p, miR-138-5p, miR-140-3p, miR-142-5p, miR-146a-5p;

< 1e-325

Catabolic process (GO:0009056)

1146

RNF41, VPS4A, ABCD4, ERLIN1, YTHDC2, PPP1CA, RAB2B, RPA1;

26

miR-142-5p, miR-146a-5p, miR-181a-5p, miR-181b-5p, miR-185-5p;

< 1e-325

Generation of precursor metabolites and energy (GO:0006091)

163

NDUFS2, PPP1CA, FASN, PRKCA, PYGL, PFKP, COX8A, ACOX1;

14

let-7b-5p, let-7i-5p, miR-181b-5p, miR-185-5p, miR-27b-3p;

1.11e-16

Transcription factor binding (GO:0008134)

233

FHL2, TRIP6, ACTB, NACA, TCF3, HIPK2, STAT3, HOXA7, PAX6;

16

miR-181b-5p, miR-27b-3p, miR-30e-5p, miR-532-5p;

4.10e-15