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Table 1 Significant KEGG pathways enriched in the identified miRNAs differentially expressed in females vs. males

From: MicroRNA profiling of the pig periaqueductal grey (PAG) region reveals candidates potentially related to sex-dependent differences

KEGG pathway Number of genes Examples of genes Number of miRNAs Examples of miRNAs p value
Fatty acid metabolism (hsa01212) 34 ACSL5, FASN, MCAT, ACADSB, ACSL3, PTPLB, ACOX1, PECR, ACOX3, HADH; 19 miR-124-3p, miR-142-5p, miR-27b-3p, miR-30a-5p, miR-181a-5p; 6.23e-08
Estrogen signaling pathway (hsa04915) 73 ESR1, BABBR1, FOS, HBEGF, ADCY1, SOS2, ATF2, ADCY7, NRAS, MAP2K2; 30 miR-103a-3p, miR-148a-3p, miR-27b-3p, miR-28-3p, miR-532-5p; 4.50e-06
Oocyte meiosis (hsa04114) 78 SLK, ESPL1, PPP1CA, FBXO5, CAMK2D, PPP2R5E, SMC1A, YWHAH, ADCY1, CCNB1; 30 miR-92b-3p, miR-30a-5p, miR-365a-3p, let-7i-5p, miR-708-5p; 0.00015
Endometrial cancer (hsa05213) 40 BRAF, GSK3B, ERBB2, SOS2, NRAS, MAP2K2, APC, PIK3CB, TCF7L2, RAF1; 27 miR-138-5p, miR-181b-5p, miR-126-3p, miR-146a-5p, miR-676-3p; 0.00108
Progesterone-mediated oocyte maturation (hsa04914) 65 BRAF, ADCY1, CCNB1, PGR, CCNA7, BUB1, FZR1, GNAI3, ANAPC2, ARAF; 29 miR-592, let-7b-5p, miR-124-3p, miR-181a-5p, miR-30e-5p; 0.00116
Prolactin signaling pathway (hsa04917) 52 ESR1, PRLR, FOS, GSK3B, STAT3, NFKB1, SOCS4, SOS2, CISH, JAK2; 28 miR-490-3p, let-7i-5p, miR-124-3p, miR-191-5p; 0.00221
Long-term depression (hsa04730) 39 BRAF, PRKCA, GNA12, NRAS, GNAS, GNA13, PLA2G4F, GNAQ, ITPR3; 29 miR-124-3p, miR-92b-3p, miR-365a-3p, miR-708-5p, miR-181a-5p; 0.00420
Steroid biosynthesis (hsa00100) 14 SS5D, TM7SF2, MSMO1, DHCR24, CYP51A1, SOAT1, LSS, SQLE; 21 miR-30a-5p, miR-30b-5p, miR-30e-5p, miR-148a-3p; 0.00709
Axon guidance (hsa04360) 78 EFNB2, SEMA6A, PLXNA2, GSK3B, MET, ROCK1, L1CAM, FES, RHOA; 30 miR-124-3p, miR-148a-3p, miR-676-3p, miR-99b-5p; 0.04447
  1. Upregulated miRNAs are in bold