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Table 1 Significant KEGG pathways enriched in the identified miRNAs differentially expressed in females vs. males

From: MicroRNA profiling of the pig periaqueductal grey (PAG) region reveals candidates potentially related to sex-dependent differences

KEGG pathway

Number of genes

Examples of genes

Number of miRNAs

Examples of miRNAs

p value

Fatty acid metabolism (hsa01212)

34

ACSL5, FASN, MCAT, ACADSB, ACSL3, PTPLB, ACOX1, PECR, ACOX3, HADH;

19

miR-124-3p, miR-142-5p, miR-27b-3p, miR-30a-5p, miR-181a-5p;

6.23e-08

Estrogen signaling pathway (hsa04915)

73

ESR1, BABBR1, FOS, HBEGF, ADCY1, SOS2, ATF2, ADCY7, NRAS, MAP2K2;

30

miR-103a-3p, miR-148a-3p, miR-27b-3p, miR-28-3p, miR-532-5p;

4.50e-06

Oocyte meiosis (hsa04114)

78

SLK, ESPL1, PPP1CA, FBXO5, CAMK2D, PPP2R5E, SMC1A, YWHAH, ADCY1, CCNB1;

30

miR-92b-3p, miR-30a-5p, miR-365a-3p, let-7i-5p, miR-708-5p;

0.00015

Endometrial cancer (hsa05213)

40

BRAF, GSK3B, ERBB2, SOS2, NRAS, MAP2K2, APC, PIK3CB, TCF7L2, RAF1;

27

miR-138-5p, miR-181b-5p, miR-126-3p, miR-146a-5p, miR-676-3p;

0.00108

Progesterone-mediated oocyte maturation (hsa04914)

65

BRAF, ADCY1, CCNB1, PGR, CCNA7, BUB1, FZR1, GNAI3, ANAPC2, ARAF;

29

miR-592, let-7b-5p, miR-124-3p, miR-181a-5p, miR-30e-5p;

0.00116

Prolactin signaling pathway (hsa04917)

52

ESR1, PRLR, FOS, GSK3B, STAT3, NFKB1, SOCS4, SOS2, CISH, JAK2;

28

miR-490-3p, let-7i-5p, miR-124-3p, miR-191-5p;

0.00221

Long-term depression (hsa04730)

39

BRAF, PRKCA, GNA12, NRAS, GNAS, GNA13, PLA2G4F, GNAQ, ITPR3;

29

miR-124-3p, miR-92b-3p, miR-365a-3p, miR-708-5p, miR-181a-5p;

0.00420

Steroid biosynthesis (hsa00100)

14

SS5D, TM7SF2, MSMO1, DHCR24, CYP51A1, SOAT1, LSS, SQLE;

21

miR-30a-5p, miR-30b-5p, miR-30e-5p, miR-148a-3p;

0.00709

Axon guidance (hsa04360)

78

EFNB2, SEMA6A, PLXNA2, GSK3B, MET, ROCK1, L1CAM, FES, RHOA;

30

miR-124-3p, miR-148a-3p, miR-676-3p, miR-99b-5p;

0.04447

  1. Upregulated miRNAs are in bold