Fig. 8

Transgene expression modulated the post-burst AHP potential in 20-month-old mice. a An example of a recorded EC neuron following an injection of a 50-ms depolarizing current. Post-burst AHP potential is estimated in relation with the resting potential (the dashed line) and is abolished when calcium is removed from the extracellular solution. b Representation of a post-burst hyperpolarization (zoomed from the square in a). c An example of recordings illustrating post-burst hyperpolarization in neurons from male (c) or female (d) expressing or not 3xTg-AD transgenes. Transgene expression increased the amplitude of post-burst AHP only in females (e) and elevated the decay time in both sexes (f). The number of mice included in each group was 5 for NonTg males, 5 for 3xTg-AD males, 9 for NonTg females, and 4 for 3xTg-AD females. Statistical comparisons were performed using two-way ANOVA (f) or unpaired Student’s t test (e). *p < 0.05, **p < 0.01