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Fig. 6 | Biology of Sex Differences

Fig. 6

From: Sex-dependent alterations in the physiology of entorhinal cortex neurons in old heterozygous 3xTg-AD mice

Fig. 6

Transgene expression increased firing activity and reduced firing accommodation in both males and females aged of 20 months. Transgene expression increased F-I slopes (a) and reduced firing accommodation (b) in 3xTg-AD mice of both sexes. c The rheobase was not influenced by 3xTg-AD expression or sex and was estimated from the F-I plot using graphical methods. The number of mice included in each group was 5 for NonTg males, 14 for 3xTg-AD males, 12 for NonTg females, and 6 for 3xTg-AD females. Statistical comparisons were performed using two-way ANOVA (a, b) or Welch’s t test (c). Abbreviations: F-I, firing rate versus injected current. *p < 0.05, **p < 0.01

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