Fig. 1

Aβ pathology was more pronounced in 20-month-old heterozygous 3xTg-AD females. a, b Levels of both sAβ40 and sAβ42 were higher in transgenic females compared to males. c The sAβ42/sAβ40 ratio was not influenced by sex. d, e In insoluble fractions, amounts of iAβ40 and iAβ42 were more elevated in transgenic females. f The sex of animals did not modulate the iAβ42/iAβ40 ratio in insoluble fractions. Statistical comparisons were performed using Welch’s t test (a, d, and e) or unpaired Student’s t test (b, c, and f). *p < 0.05, **p < 0.01, ***p < 0.001