TY - JOUR AU - Szczepanski, Jamie AU - Spencer, Shauna-Kay AU - Griffin, Ashley AU - Bowles, Teylor AU - Williams, Jan Michael AU - Kyle, Patrick B. AU - Dumas, John Polk AU - Araji, Sarah AU - Wallace, Kedra PY - 2020 DA - 2020/09/24 TI - Acute kidney injury during pregnancy leads to increased sFlt-1 and sEng and decreased renal T regulatory cells in pregnant rats with HELLP syndrome JO - Biology of Sex Differences SP - 54 VL - 11 IS - 1 AB - The incidence of acute kidney injury (AKI) during pregnancy precedes a high maternal mortality rate of 20–40%. AKI during pregnancy has multiple etiologies; however, the more common are maternal hypertensive disorders, which include preeclampsia and HELLP (hemolysis, elevated liver enzyme, low platelet) syndrome. Therefore, we sought to assess the impact of AKI on blood pressure, kidney injury, and anti-angiogenic factors during pregnancies with and without HELLP syndrome. SN - 2042-6410 UR - https://doi.org/10.1186/s13293-020-00331-6 DO - 10.1186/s13293-020-00331-6 ID - Szczepanski2020 ER -