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Fig. 3 | Biology of Sex Differences

Fig. 3

From: Sex differences in severity and mortality from COVID-19: are males more vulnerable?

Fig. 3

Spike protein of coronavirus. The schematic diagram shows the coronavirus structure (a). The spike protein (S) has S1 and S2 domains. The S protein has receptor binding domain (RBD) and the receptor binding motif (RBM) and within RBD binds ACE2. S1/S2 and S2′cleavage sites are acted by protease to assist viral fusion. RBM sequence between SARS-CoV and SARS-CoV-2 showed 46.5% identity, and the nine residues that increase RBM affinity to ACE2 are indicated in red (b). NTD, N-terminal domain; RBD, receptor binding domain; RBM, receptor binding motif; FP, fusion protein; HR1, heptad repeat 1; HR2, heptad repeat 2; TM, transmembrane domain; CT, cytoplasmic tail

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