Interactive effects of asparagine and aspartate homeostasis with sex and age for the risk of type 2 diabetes risk

Table 3 Secondary interaction of age and sex with asparagine and aspartate homeostasis for T2D

	OR (95% CI)	P value
Univariable additive interaction model
Female and > 50 years of age = no plus Asn: Asp ≤ 1.5	reference
Female and > 50 years of age = yes plus Asn: Asp ≤ 1.5	4.53 (2.57–7.98)	< .0001
Female and > 50 years of age = no plus Asn: Asp > 1.5	6.76 (4.70–9.71)	< .0001
Female and > 50 years of age = yes plus Asn: Asp > 1.5	52.9 (34.4–81.2)	< .0001
Interaction measure	Estimates
RERI	42.6 (22.7–62.5)
AP	0.81 (0.74–0.87)
S	5.58 (3.90–8.00)
Multivariable additive interaction model
Female and > 50 years of age = no plus Asn: Asp ≤ 1.5	reference
Female and > 50 years of age = yes plus Asn: Asp ≤ 1.5	2.78 (1.35–5.71)	0.0053
Female and > 50 years of age = no plus Asn: Asp > 1.5	6.50 (4.24–9.95)	< .0001
Female and > 50 years of age = yes plus Asn: Asp > 1.5	34.4 (20.5–57.5)	< .0001
Interaction measure	Estimates
RERI	26.1 (11.0–41.2)
AP	0.76 (0.66–0.86)
S	4.58 (2.96–7.08)

Abbreviations: T2D type 2 diabetes, OR odds ratio, CI confidence interval, RERI risk due to interaction, AP attributable proportion due to interaction, S synergy index
Multivariable analysis adjusted for body mass index (< 18.5, 18.5 ~ 24.0, 24.0 ~ 28.0, and ≥ 28.0 kg/m2), systolic blood pressure (< 140 and ≥ 140 mmHg), low-density lipoprotein cholesterol (< 2.60 and ≥ 2.60 mmol/L), high-density lipoprotein cholesterol (< 1.00 mmol/L in male or < 1.30 mmol/L in female as low level and ≥ 1.00 in male or ≥1.30 in female as high level) and triglyceride (< 1.70 mmol/L and ≥ 1.70 mmol/L); significant elative excess risk due to interaction (RERI) > 0, attributable proportion due to interaction (AP) > 0, or synergy index (S) > 1 indicates a significant additive interaction

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