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Fig. 4 | Biology of Sex Differences

Fig. 4

From: Hypogonadal hypertension in male Sprague-Dawley rats is renin-angiotensin system-dependent: role of endogenous androgens

Fig. 4

rt-PCR for mRNA expression of renin-angiotensin system (RAS) components in the kidneys of male Sprague-Dawley (SD) rats: intact (InT-control), bilaterally castrated (CsX), or CsX with TES therapy (CsX-TRT; 1.75 mg kg−1; sc, 2x/week). Values are expressed as the ratio of RAS component mRNA to elongation factor-1 (EF-1) mRNA levels obtained from the same tissues. Bars represent means ± SEM (n = 6-9 rats per group). a, b, and c indicate the mean values for mRNA expression of renin, angiotensinogen (Agt), angiotensin-converting enzyme (ACE), or angiotensin II receptor type I (AT1R) among the three experimental groups (InT-Control, CsX, and CsX-TRT) without common script are significantly different (0.0013 ≤ P ≤ 0.033)

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