Fig. 2
Weekly systolic blood pressure (BP) measurements of bilaterally castrated (CsX) male Sprague-Dawley (SD) rats: CsX with TES therapy administered from weeks 10-15 (CsX-TRT; 1.75 mg kg−1; sc, 2x/week), or CsX with DHT therapy administered from weeks 10-15 (CsX-DRT; 1.00 mg kg−1; sc, 2x/week). A separate group of CsX SD rats with TES therapy administered from weeks 10-15 (1.75 mg kg−1; sc, 2x/week) also received losartan-potassium (LST), an AT1R antagonist, in their drinking water (250 mg/L) for the entire 15-week experimental period (CsX-TES-LST). Data points are means ± SEM (n = 5-10 rats per group). a, b, and c indicate that among the four experimental groups (CsX, CsX-TRT, CsX-DHT, and CsX-LST), mean values at each time point (5, 10, or 15 weeks) without common script are significantly different (0.0001 ≤ P ≤ 0.02). Plus sign, number sign, and asterisk for each experimental group (CsX, CsX-TRT, CsX-DHT, or CsX-LST), mean values over time (5, 10, and 15 weeks) without common script are significantly different (0.0001 ≤ P ≤ 0.02)