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Table 3 Adjusted and multiple testing-corrected circulating proteins associated with female sex

From: Sex differences in circulating proteins in heart failure with preserved ejection fraction

  Clinical model (AUC 0.82) Proteins
  OR (95% CI) for female sex association p value OR (95% CI) for female sex association p value
Heart rate, per 10 bpm increase 1.22 (1.00–1.48) 0.049   
Total cholesterol, per 10 mg/dL increase 1.13 (1.03–1.02) 0.010   
Smoking status     
 Never Ref.   
 Former 0.21 (0.12–0.36) < 0.001   
 Current 0.33 (0.14–0.80) 0.014   
CAD 0.36 (0.21–0.62) < 0.001   
Previous HF hospitalization 0.47 (0.27–0.82) 0.008   
Hb, per 1 g/dL increase 0.69 (0.57–0.82) < 0.001   
Higher expression in females vs. males     
 IL1RL2    4.13 (2.22–7.68) < 0.001
 LPL    4.08 (2.44–6.82) < 0.001
 LHB    3.15 (2.20–4.52) < 0.001
 IGFBP3    2.83 (1.74–4.58) < 0.001
 PLIN1    2.44 (1.62–3.66) < 0.001
 Ep-CAM    1.87 (1.41–2.48) < 0.001
Less expression in females vs. males     
 NRP1    0.05 (0.01–0.19) < 0.001
 MMP-3    0.22 (0.14–0.35) < 0.001
 ACE2    0.41 (0.28–0.61) < 0.001
  1. Each OR unit increase represents doubling in the NPX values
  2. Legend: eGFR estimated glomerular filtration rate, OR odds ratio, CI confidence interval, AUC area under the curve, bpm beats per minute, CAD coronary artery disease, HF heart failure, Hb hemoglobin, IGFBP3 insulin-like growth factor-binding protein 3, NRP1 neuropilin 1, IL1RL2 interleukin-1 receptor-like 2, LPL lipoprotein lipase, ACE2 angiotensin-converting enzyme 2, Ep_CAM epithelial cell adhesion molecule, CA14 carbonic anhydrase 14, PLIN1 perilipin-1, LHB lutropin subunit beta
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