An interaction between fetal sex and placental weight and efficiency predicts intrauterine growth in response to maternal protein insufficiency and gestational exposure window in a mouse model of FASD

Table 6 Correlation of the anthropometric measurements of the fetuses from dams in Groups 1 and 3 with their placental weight and efficiency

	Correlation with placental weight			Correlation with placental efficiency
	R	P_unadjusted	P_BH-adjusted	R	P_unadjusted	P_BH-adjusted
Males only
Fetal body weight	0.15	0.20	0.32	0.73	< 0.001	< 0.001*
Fetal brain-to-body weight ratio	0.05	0.65	0.74	− 0.55	< 0.001	< 0.001*
Fetal heart-to-body weight ratio	− 0.09	0.43	0.57	− 0.10	0.42	0.48
Fetal liver-to-body weight ratio	0.25	0.036	0.09	− 0.18	0.12	0.19
Fetal brain-to-liver weight ratio	− 0.23	0.046	0.09	0.01	0.95	0.95
Females only
Fetal body weight	0.17	0.10	0.13	0.65	< 0.001	< 0.001*
Fetal brain-to-body weight ratio	− 0.21	0.036	0.072	− 0.33	0.001	0.002*
Fetal heart-to-body weight ratio	− 0.19	0.059	0.09	− 0.06	0.54	0.62
Fetal liver-to-body weight ratio	0.44	< 0.001	< 0.001*	− 0.19	0.064	0.10
Fetal brain-to-liver weight ratio	− 0.42	< 0.001	< 0.001*	0.03	0.79	0.79

Litters from all 4 treatments were combined and included in the analyses. The sample sizes were n = 9 litters for NP-MD-8, LP-MD-8, and LP-Alc-8 groups; n = 8 litters for NP-Alc-8 group. P values before and after multiple testing adjustment using Benjamini-Hochberg method are presented
*Statistical significance at P < 0.05

ISSN: 2042-6410