Fig. 6

Converging trend during hepatocarcinogenesis between males and females of Hras12V transgenic mice. a Principal-component analysis (PCA) of all quantified proteins in samples (a, MW; b, MP; c, MT; d, FW; e, MP; f, MT). b mRNA levels of Ar and Esr1 in W, P, and T of males and females as detected by RT-qPCR. c The mRNA levels of female-prevalent enzymes CYP2B13 and SULT2A2 and male-prevalent enzymes CYP2D9, CYP7B1, UGT2B1, and HSD3B5 in W, P, and T of male and female mice as detected by RT-qPCR. The mRNA levels of the genes were normalized to Rp135a. The data are expressed as the mean ± SEM (n = 5–7).*p < 0.05; **p < 0.01.