Fig. 1

Analysis and validation of the quality of quantitative proteomics data. Unsupervised hierarchical clustering of all proteome datasets shows separation among the different groups. Protein expression levels are color-coded, showing higher and lower expression in red and blue, respectively. MW, normal liver tissues of non-transgenic 9-months-old males; MP, precancerous tissues of transgenic 9-months-old males; MT, hepatocellular carcinoma tissues of transgenic 9-months-old males; FW, normal liver tissues of non-transgenic 15-months-old females; FP, precancerous tissues of transgenic 15-months-old females; FT, hepatocellular carcinoma tissues of transgenic 15-months-old females. The numbers indicate different individuals or different composite samples