A new sex-specific underlying mechanism for female schizophrenia: accelerated skewed X chromosome inactivation

Table 3 The relationship between the degree of skewed XCI and clinical symptoms in MDD

MDD patient		Patient age (years)	Age of onset (years)	Disease duration (months)	HAMD	Medicine (mg/day)
Total patient	Coefficient	0.123	−0.007	−0.167	0.138	−0.16
	Significance	0.451	0.966	0.323	0.415	0.33
Adult patient	Coefficient	−0.165	−0.029	−0.186	0.41	0.109
	Significant	0.462	0.896	0.408	0.058	0.688
Elderly patient	Coefficient	−0.147	−0.235	−0.385	−0.086	−0.321
	Significance	0.586	0.4	0.157	0.759	0.145

The relationship between degree of skewed XCI and clinical indicators analyzed by Spearman's correlation and Spearman's correlation was significant at p < 0.025 for age group of MDD patients.
†Positive symptoms in the PANSS
§Negative symptoms in the PANSS