Table 1 Genotypic frequencies of subjects enrolled in the study and the prevalence of skewed X chromosome inactivation
Group 1 | Group 2 | Total no. of women enrolled in the study | Age (mean and standard deviation) | No. of women heterozygous at the HUMARA locus | No. of individuals with skewing ≥75% | % of skewing ≥75% | OR | CI | p-value | No. of individuals with skewing ≥80% | % of skewing ≥80% | OR | CI | p-value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CNTL | SUM | 80 | 28.61±14.6 | 80 | 10 | 12.5 |  |  |  | 5 | 6.25 |  |  |  |
|  | Child | 20 | 13.35±4.65 | 20 | 1 | 5 |  |  |  | 0 | 0 |  |  |  |
|  | Adult | 47 | 27.23±3.67 | 47 | 6 | 12.2 |  |  |  | 3 | 6.1 |  |  |  |
|  | Elderly | 13 | 57.07±7.27 | 13 | 3 | 23 |  |  |  | 2 | 15.3 |  |  |  |
SCZ | SUM | 109 | 27.7±15.00 | 101 | 29 | 28.7 | 2.8 | 1.2-6.2 | p=0.01 | 20 | 19.8 | 3.7 | 1.3-10.3 | p=0.009 |
|  | Child | 45 | 15.12±2.14 | 39 | 6 | 15.3 | 3.4 | 0.4-3.8 | p=0.404 | 3 | 7.6 | 1.5 | 0.8-1.0 | p=0.156 |
|  | Adult | 48 | 27.89±4.39 | 46 | 18 | 39 | 4.3 | 1.3-12 | p=0.005 | 14 | 30 | 6.4 | 1.7-24 | P=0.006 |
|  | Elderly | 16 | 57.81±7.23 | 16 | 5 | 31 | 1.5 | 0.3-8.0 | p=0.67 | 3 | 19 | 1.2 | 0.18-9.0 | p=0.81 |
MDD | SUM | 38 | 38.31±15.3 | 38 | 7 | 18.4 | 1.8 | 0.6-5 | p=0.392 | 6 | 15.7 | 1.7 | 0.4-6.9 | p=0.1 |
|  | Adult | 22 | 25.86±4.15 | 22 | 4 | 18 | 0.7 | 0.4-6.0 | p=0.714 | 4 | 18 | 3.2 | 0.6-16 | p=0.192 |
|  | Elderly | 16 | 55.44±4.37 | 16 | 3 | 19 | 0.8 | 0.1-4.6 | p=1 | 2 | 13 | 1.1 | 0.16-8.1 | p=1 |