|
Group 1
|
Group 2
|
Total no. of women enrolled in the study
|
Age (mean and standard deviation)
|
No. of women heterozygous at the HUMARA locus
|
No. of individuals with skewing ≥75%
|
% of skewing ≥75%
|
OR
|
CI
|
p-value
|
No. of individuals with skewing ≥80%
|
% of skewing ≥80%
|
OR
|
CI
|
p-value
|
|---|
|
CNTL
|
SUM
|
80
|
28.61±14.6
|
80
|
10
|
12.5
| | | |
5
|
6.25
| | | |
| |
Child
|
20
|
13.35±4.65
|
20
|
1
|
5
| | | |
0
|
0
| | | |
| |
Adult
|
47
|
27.23±3.67
|
47
|
6
|
12.2
| | | |
3
|
6.1
| | | |
| |
Elderly
|
13
|
57.07±7.27
|
13
|
3
|
23
| | | |
2
|
15.3
| | | |
|
SCZ
|
SUM
|
109
|
27.7±15.00
|
101
|
29
|
28.7
|
2.8
|
1.2-6.2
|
p=0.01
|
20
|
19.8
|
3.7
|
1.3-10.3
|
p=0.009
|
| |
Child
|
45
|
15.12±2.14
|
39
|
6
|
15.3
|
3.4
|
0.4-3.8
|
p=0.404
|
3
|
7.6
|
1.5
|
0.8-1.0
|
p=0.156
|
| |
Adult
|
48
|
27.89±4.39
|
46
|
18
|
39
|
4.3
|
1.3-12
|
p=0.005
|
14
|
30
|
6.4
|
1.7-24
|
P=0.006
|
| |
Elderly
|
16
|
57.81±7.23
|
16
|
5
|
31
|
1.5
|
0.3-8.0
|
p=0.67
|
3
|
19
|
1.2
|
0.18-9.0
|
p=0.81
|
|
MDD
|
SUM
|
38
|
38.31±15.3
|
38
|
7
|
18.4
|
1.8
|
0.6-5
|
p=0.392
|
6
|
15.7
|
1.7
|
0.4-6.9
|
p=0.1
|
| |
Adult
|
22
|
25.86±4.15
|
22
|
4
|
18
|
0.7
|
0.4-6.0
|
p=0.714
|
4
|
18
|
3.2
|
0.6-16
|
p=0.192
|
| |
Elderly
|
16
|
55.44±4.37
|
16
|
3
|
19
|
0.8
|
0.1-4.6
|
p=1
|
2
|
13
|
1.1
|
0.16-8.1
|
p=1
|
- Considered skewed if the inactivation of the predominant allele was ≥75% or 80%, ORs and values for patients vs the age-matched heathy control group. SCZ vs CNTL, p<0.05*; age group SCZ vs CNTL, p<0.0167 * or age group MDD vs CNTL, p<0.025* by Fisher’s exact test or the chi-squared test. OR=odds ratio CI= confidence interval
