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Table 1 Genotypic frequencies of subjects enrolled in the study and the prevalence of skewed X chromosome inactivation

From: A new sex-specific underlying mechanism for female schizophrenia: accelerated skewed X chromosome inactivation

Group 1 Group 2 Total no. of women enrolled in the study Age (mean and standard deviation) No. of women heterozygous at the HUMARA locus No. of individuals with skewing ≥75% % of skewing ≥75% OR CI p-value No. of individuals with skewing ≥80% % of skewing ≥80% OR CI p-value
CNTL SUM 80 28.61±14.6 80 10 12.5     5 6.25    
  Child 20 13.35±4.65 20 1 5     0 0    
  Adult 47 27.23±3.67 47 6 12.2     3 6.1    
  Elderly 13 57.07±7.27 13 3 23     2 15.3    
SCZ SUM 109 27.7±15.00 101 29 28.7 2.8 1.2-6.2 p=0.01 20 19.8 3.7 1.3-10.3 p=0.009
  Child 45 15.12±2.14 39 6 15.3 3.4 0.4-3.8 p=0.404 3 7.6 1.5 0.8-1.0 p=0.156
  Adult 48 27.89±4.39 46 18 39 4.3 1.3-12 p=0.005 14 30 6.4 1.7-24 P=0.006
  Elderly 16 57.81±7.23 16 5 31 1.5 0.3-8.0 p=0.67 3 19 1.2 0.18-9.0 p=0.81
MDD SUM 38 38.31±15.3 38 7 18.4 1.8 0.6-5 p=0.392 6 15.7 1.7 0.4-6.9 p=0.1
  Adult 22 25.86±4.15 22 4 18 0.7 0.4-6.0 p=0.714 4 18 3.2 0.6-16 p=0.192
  Elderly 16 55.44±4.37 16 3 19 0.8 0.1-4.6 p=1 2 13 1.1 0.16-8.1 p=1
  1. Considered skewed if the inactivation of the predominant allele was ≥75% or 80%, ORs and values for patients vs the age-matched heathy control group. SCZ vs CNTL, p<0.05*; age group SCZ vs CNTL, p<0.0167 * or age group MDD vs CNTL, p<0.025* by Fisher’s exact test or the chi-squared test. OR=odds ratio CI= confidence interval