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Fig. 2 | Biology of Sex Differences

Fig. 2

From: A new sex-specific underlying mechanism for female schizophrenia: accelerated skewed X chromosome inactivation

Fig. 2

Age matters in the relationship between XCI skewing and schizophrenia. Red = SCZ, black = CNTL. a Scatterplot of age and the degree of XCI for CNTLs (black, r = 0.167, p = 0.138) and SCZ patients (red, r = 0.31, p = 0.002**) by Spearman’s correlation, simple linear regression (y = 0.002x + 0.61), and logistic regression (p = 0.042, OR = 1.369, 95% CI, 1.012 1.853). b X-skewing of child, adult, and elderly SCZ patients (red), and CNTLs (black) were compared by Mann-Whitney U test. Adult CNTL vs adult SCZ, p = 0.009, p < 0.0167*. c The degree of skewed XCI observed in adult CNTLs vs adult SCZ patients, p = 0.001, p < 0.0167* by unpaired-sample t test

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