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Table 3 DNA methylome alterations in less severe PE cases vs. normotensive controls

From: Systematic review supports the role of DNA methylation in the pathophysiology of preeclampsia: a call for analytical and methodological standardization

Gene No of CpGs Region DNA methylation changes Sample PE Reference
COL5A1 1 / No difference Placenta LOPE [37]
INHBA 2 5′ UTR Hypomethylated Placenta LOPE [34]
BHLHE40 1 Body Hypomethylated Placenta LOPE [34]
SLC2A1 1 Body Hypomethylated Placenta LOPE [34]
ADAM12 1 Body No difference Placenta LOPE [34]
LINE-1 / / No difference Placenta LOPE [11]
Alu / / No difference Placenta LOPE [11]
CRH Multiple 5′ UTR No difference Placenta LOPE [35]
CRHBP Multiple Intron 3 No difference Placenta LOPE [35]
LEP Multiple Promoter No difference Placenta LOPE [63]
TERT 1 (cg01934390) Promoter No difference Placenta   [48]
1 (cg11832804) Promoter    LOPE  
DNMT1 1 (cg07627628) / No difference Placenta   [48]
1 (cg26538782) /    LOPE  
NOTCH1 / Promoter No difference Placenta LOPE [57]
VEGF 23 Promoter Hypomethylated Placenta LOPE [60]
FLT-1 30 Promoter No difference Placenta LOPE [60]
KDR 37 Promoter No difference Placenta LOPE [60]
ACAP2 4 Promoter Hypermethylated Placenta LOPE [45]
CLIC6 11 Promoter Hypermethylated Placenta LOPE [45]
GATA4 9 Promoter Hypermethylated Placenta LOPE [45]
PCDH9 7 Promoter Hypermethylated Placenta LOPE [45]
PTPRN2-A 20 Promoter Hypomethylated Placenta LOPE [45]
CCDC149 / Promoter Hypermethylated Placenta LOPE [45]
PTPRN2-A / Promoter Hypermethylated Placenta LOPE [45]
PTPRN2-B / Promoter Hypermethylated Placenta LOPE [45]
RBFOX1 / Promoter Hypermethylated Placenta LOPE [45]
MASPIN (SERPINB5) / / No difference Plasma mPE [61]
MMP1 1 Promoter No difference Omental fat arteries mPE [32]