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Table 2 DNA methylome alterations in more severe PE cases vs. normotensive controls

From: Systematic review supports the role of DNA methylation in the pathophysiology of preeclampsia: a call for analytical and methodological standardization

Gene No of CpGs Region DNA methylation changes Sample PE Reference
H19 / / Hypermethylated Placenta EOPE [11]
7 Exon 1 Hypermethylated Placenta sPE [55]
CDH11 1 / Hypermethylated Placenta EOPE [37]
NCAM1 1 / Hypomethylated Placenta EOPE [37]
TNF 1 / Hypermethylated Placenta EOPE [37]
INHBA 1 5′ UTR Hypomethylated Placenta EOPE [34]
BHLHE40 1 Body Hypomethylated Placenta EOPE [34]
SLC2A1 1 Body Hypomethylated Placenta EOPE [34]
ADAM12 1 Body Hypomethylated Placenta EOPE [34]
LINE-1 / / Hypermethylated Placenta EOPE [11]
TBX15 39 Promoter Hypomethylated Placenta EOPE [43]
Alu / / Hypermethylated Placenta EOPE [11]
NR3C1 Multiple promoter Hypermethylated Placenta EOPE [35]
CRH Multiple 5′ UTR No difference Placenta EOPE [35]
CRHBP Multiple Intron 3 Hypermethylated Placenta EOPE [35]
LEP Multiple Promoter Hypomethylated Placenta EOPE [63]
TERT 1 (cg01934390) / Hypomethylated Placenta EOPE [48]
TNFAIP8 1 / Hypomethylated Placenta EOPE [64]
YWHAQ (T-14-tau)) 19 Promoter Hypermethylated Placenta sPE [56]
WNT2 7 Promoter No difference Placenta EOPE [66]
DNMT1 1 (cg07627628) / Hypomethylated Placenta EOPE [48]
1 (cg26538782) / Hypermethylated    
DNMT3A 1 (cg11779362) / Hypomethylated Placenta EOPE [48]
DLL1 / Promoter Hypermethylated Placenta EOPE [57]
NOTCH1 / Promoter No difference Placenta EOPE [57]
VEGF 23 Promoter Hypermethylated Placenta EOPE [60]
FLT-1 30 Promoter No difference Placenta EOPE [60]
KDR 37 Promoter No difference Placenta EOPE [60]
AKT1 1 / Hypomethylated Placenta EOPE [19]
CRTC1 1 / Hypomethylated Placenta EOPE [19]
PER1 1 / Hypomethylated Placenta EOPE [19]
CSKN1E 1 / Hypomethylated Placenta EOPE [19]
PRDX1 1 / Hypomethylated Placenta EOPE [19]
RORA 1 / Hypomethylated Placenta EOPE [19]
ARNTL2 1 / Hypomethylated Placenta EOPE [19]
CLOCK 2 / Hypomethylated Placenta EOPE [19]
CRY2 3 / Hypomethylated Placenta EOPE [19]
PER2 4 / Hypomethylated Placenta EOPE [19]
FOXO3 5 / Hypomethylated Placenta EOPE [19]
MAPK1 2 / Hypomethylated Placenta EOPE [19]
PRDX5 1 / Hypomethylated Placenta EOPE [19]
PRKCA 2 / Hypomethylated Placenta EOPE [19]
CAPG 2 Promoter Hypomethylated Placenta EOPE [28]
GLI2 2 Promoter Hypomethylated Placenta EOPE [28]
KRT13 2 Promoter Hypomethylated Placenta EOPE [28]
NuRD / Promoter Hypermethylation Placenta EOPE [58]
BARX / Promoter Hypermethylation Placenta EOPE [58]
E2F4 / Promoter Hypomethylation Placenta EOPE [58]
MMP9 1 Promoter Hypermethylation Placenta sPE [59]
C12orf75 1 body Hypomethylation Placenta EOPE [54]
PVT1_MIR1204 1 TSS200 Hypomethylation Placenta EOPE [54]
NDUFAF3 1 TSS200 Hypomethylation Placenta EOPE [54]
ARSG 1 body Hypomethylation Placenta EOPE [54]
FYCO1 1 body Hypomethylation Placenta EOPE [54]
SULF2 1 5′ UTR Hypomethylation Placenta EOPE [54]
PVT1 1 body Hypomethylation Placenta EOPE [54]
OBSL1 1 body Hypomethylation Placenta EOPE [54]
MERTK 1 body Hypomethylation Placenta EOPE [54]
C2 1 1st exon Hypomethylation Placenta EOPE [54]
PEBP1 1 body Hypomethylation Placenta EOPE [54]
SKI 1 body Hypomethylation Placenta EOPE [54]
CCDC68 1 TSS200 Hypomethylation Placenta EOPE [54]
DKK1 5 Promoter No difference Placenta EOPE [66]
TIMP-3 / / No difference Serum sPE [65]
2 Promoter Hypomethylated Placenta EOPE [28]
RASSF1A / / No difference Serum sPE [65]
CDH1 / / No difference Serum sPE [65]
PTGS2 / / No difference Serum sPE [65]
BLT1 / / No difference Serum sPE [65]
APC / / Hypomethylated Serum sPE [65]
/ / Hypermethylated Plasma sPE [61]
HYP2 / / Hypermethylated Plasma EOPE [62]
MASPIN (SERPINB5) / / Hypomethylated Plasma sPE [61]
FAS 1 / Hypermethylated UCB EOPE [43]
ACTA2 1 / Hypermethylated UCB EOPE [43]
PI3KR1 1 / Hypermethylated UCB EOPE [43]
MIR145 2 / Hypermethylated UCB EOPE [43]
LOC728264 2 / Hypermethylated UCB EOPE [43]
IL12B 1 / Hypermethylated UCB EOPE [43]
IGF1 1 / No difference UCB EOPE [43]
MIR24-2 1 / Hypermethylated UCB EOPE [43]
MMP1 1 Promoter Hypomethylated Omental fat arteries sPE [43]