Fig. 1
From: Androgens’ effects on cerebrovascular function in health and disease
Androgen metabolism and signaling in the cerebral vasculature. Signaling pathways are indicated using green arrows. Metabolic pathways are indicated using blue arrows, and metabolizing enzymes are in purple. Confirmed expression in cells of the cerebral vasculature is indicated by cartoon cell types (see key). AR, androgen receptor; ER, estrogen receptor; HSD, Hydroxysteroid dehydrogenase; ZIP9, Zrt- and Irt-like protein 9; GPRC6a, G-protein-coupled receptor C6A; GPER1, G-protein-coupled estrogen receptor