Skip to main content

Table 3 Differences in immune-activation markers between the gut and PBMC

From: Sex-related differences in markers of immune activation in virologically suppressed HIV-infected patients

 All (PBMC)All (GUT) Male (PBMC)Male (GUT) Female (PBMC)Female (GUT) 
MarkersMean ± SEMean ± SEpvalueMean ± SEMean ± SEpvalueMean ± SEMean ± SEpvalue
CD4+naïve CD38+15.82 ± 4.0718.92 ± 3.700.5757.49 ± 1.2517.79 ± 3.020.00625.08 ± 4.9720.18 ± 4.510.472
CD4+naïve CD38+HLA-DR+1.75 ± 0.708.97 ± 1.920.0010.54 ± 0.159.59 ± 1.680.0013.10 ± 0.888.28 ± 2.260.047
CD4+naïve HLA-DR+4.97 ± 2.2117.21 ± 2.450.0012.56 ± 0.4617.94 ± 2.140.0017.65 ± 2.9516.39 ± 2.870.044
CD4+TCM CD38+10.89 ± 2.7112.69 ± 2.510.62810.14 ± 0.7714.17 ± 2.240.10811.72 ± 3.7511.05 ± 2.850.889
CD4+TCM CD38+HLA-DR+1.47 ± 0.235.89 ± 1.670.0141.5 ± 0.208.78 ± 1.990.0031.44 ± 0.592.68 ± 0.630.164
CD4+TCM HLA-DR+2.94 ± 2.8813.60 ± 2.890.0127.34 ± 2.1614.25 ± 2.150.0326.12 ± 1.1712.88 ± 3.680.100
CD4+TEM CD38+4.35 ± 0.7010.50 ± 2.030.0074.65 ± 0.6811.03 ± 1.880.0054.02 ± 0.839.91 ± 2.290.028
CD4+TEM CD38+HLA-DR+2.30 ± 0.306.02 ± 1.320.0102.60 ± 0.326.26 ± 1.560.0361.96 ± 0.445.74 ± 1.080.005
CD4+TEM HLA-DR+11.96 ± 1.2620.18 ± 2.430.00511.52 ± 1.0816.94 ± 2.230.04112.46 ± 1.7723.77 ± 2.430.001
CD8+naïve CD38+12.45 ± 3.317.71 ± 1.920.2235.99 ± 0.767.60 ± 1.930.44819.63 ± 3.947.83 ± 2.020.015
CD8+naïve CD38+HLA-DR+1.36 ± 0.356.85 ± 1.710.0040.76 ± 0.155.18 ± 1.260.0042.02 ± 0.438.72 ± 2.060.006
CD8+naïve HLA-DR+4.38 ± 0.7721.68 ± 3.870.0013.75 ± 0.3917.33 ± 1.570.0015.07 ± 1.0126.52 ± 5.250.001
CD8+TCM CD38+6.13 ± 2.109.72 ± 2.160.2404.30 ± 0.7910.42 ± 2.070.0138.16 ± 2.798.94 ± 2.360.834
CD8+TCM CD38+HLA-DR+4.09 ± 0.699.32 ± 2.220.0325.10 ± 0.769.83 ± 2.260.0642.96 ± 0.488.74 ± 2.310.027
CD8+TCM HLA-DR+8.54 ± 1.5120.23 ± 3.880.0088.81 ± 1.5818.52 ± 1.770.0018.24 ± 1.4522.14 ± 5.470.027
CD8+TEM CD38+6.50 ± 2.5614.77 ± 2.640.0293.74 ± 0.4015.75 ± 2.560.0019.57 ± 3.4913.67 ± 2.840.372
CD8+TEM CD38+HLA-DR+4.25 ± 0.5813.33 ± 2.890.0044.11 ± 0.5712.36 ± 3.100.0204.41 ± 0.6014.40 ± 2.810.003
CD8+TEM HLA-DR+11.40 ± 1.2719.88 ± 3.550.03110.82 ± 1.2415.08 ± 1.890.07212.05 ± 1.5225.21 ± 4.500.013
CD4+naïve Th11.84 ± 0.815.26 ± 2.050.1292.21 ± 1.102.09 ± 0.870.9331.42 ± 0.338.78 ± 2.610.014
CD4+naïve Th170.01 ± 0.010.18 ± 0.070.0300.01 ± 0.000.06 ± 0.040.2030.01 ± 0.010.32 ± 0.090.005
CD4+naïve Th1 Th170.13 ± 0.022.37 ± 0.670.0030.13 ± 0.031.82 ± 0.660.0230.14 ± 0.022.97 ± 0.690.001
CD4+TCM Th110.87 ± 3.4120.77 ± 4.500.0869.38 ± 3.9312.31 ± 3.110.56412.53 ± 2.9130.17 ± 4.700.004
CD4+TCM Th170.06 ± 0.021.57 ± 0.470.0040.03 ± 0.010.92 ± 0.340.0230.09 ± 0.032.30 ± 0.550.001
CD4+TCM Th1 Th170.46 ± 0.113.20 ± 1.080.0180.38 ± 0.101.32 ± 0.320.0150.55 ± 0.135.29 ± 1.380.004
CD4+TEM Th115.03 ± 4.3918.79 ± 4.820.56710.92 ± 4.677.34 ± 2.050.49119.59 ± 4.0031.51 ± 4.950.073
CD4+TEM Th170.13 ± 0.041.94 ± 0.670.0120.07 ± 0.030.56 ± 0.200.0390.2 ± 0.053.49 ± 0.800.001
CD4+TEM Th1 Th170.49 ± 0.133.54 ± 1.340.0320.26 ± 0.060.93 ± 0.330.0730.74 ± 0.166.43 ± 1.650.004
CD8+naïve Tc17.99 ± 2.7021.18 ± 6.030.0535.87 ± 2.6510.75 ± 3.330.26310.33 ± 2.7732.76 ± 7.090.009
CD8+naïve Tc170.04 ± 0.030.27 ± 0.100.0450.01 ± 0.000.10 ± 0.030.0530.07 ± 0.040.46 ± 0.130.014
CD8+naïve Tc1 Tc170.15 ± 0.050.99 ± 0.420.0570.09 ± 0.020.51 ± 0.160.0250.22 ± 0.071.53 ± 0.570.040
CD8+TCM Tc126.81 ± 7.5932.40 ± 6.840.58719.82 ± 7.7321.59 ± 5.050.84934.58 ± 7.3344.41 ± 7.480.357
CD8+TCM Tc170.14 ± 0.070.36 ± 0.120.1350.08 ± 0.030.21 ± 0.090.2160.21 ± 0.100.53 ± 0.140.081
CD8+TCM Tc1 Tc170.26 ± 0.120.51 ± 0.140.2200.13 ± 0.040.33 ± 0.110.1360.42 ± 0.170.71 ± 0.160.240
CD8+TEM Tc126.30 ± 7.4630.65 ± 7.300.67818.13 ± 7.8113.99 ± 3.610.63635.37 ± 6.7049.15 ± 7.520.183
CD8+TEM Tc170.03 ± 0.010.29 ± 0.140.0840.01 ± 0.000.12 ± 0.100.3010.06 ± 0.010.47 ± 0.170.028
CD8+TEM Tc1 Tc170.07 ± 0.030.44 ± 0.150.0260.03 ± 0.000.30 ± 0.130.0550.12 ± 0.040.59 ± 0.170.019
  1. Columns show marker name, mean ± sigma values of each marker expressed in the gut and PBMC of all patients, men and women, p value. The statistical significance is achieved when p < 0.05. Statistical differences between the gut and PBMC were evaluated using Student’s t tests