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Table 6 Cluster membership in relation to cancer incidence in Iranian population in the Tehran Lipid and Glucose Study (1999–2014)

From: Sex-specific clustering of metabolic risk factors and cancer risk: a longitudinal study in Iran

  Model 1a Model 2b
HR (95% CI) P value HR (95% CI) P value
Men
Cluster 5 Reference Reference
Cluster 1 5.38 (1.89–15.33) 0.002 2.56 (0.89–7.39) 0.080
Cluster 2 5.17 (1.73–15.49) 0.003 2.65 (0.87–8.03) 0.083
Cluster 3 7.75 (2.73–22.01) 0.003 3.56 (1.23–10.28) 0.018
Cluster 4 4.76 (1.66–13.61) 0.001 2.46 (0.85–7.11) 0.096
Cluster 6 2.60 (0.78–8.63) 0.118 3.05 (0.91–10.14) 0.068
Cluster 7 2.58 (0.87–7.65) 0.085 2.23 (0.75–6.62) 0.146
Women
Cluster 2 Reference Reference
Cluster 1 2.92 (1.28–6.63) 0.010 2.23 (0.97–5.13) 0.057
Cluster 3 2.32 (0.98–5.49) 0.054 1.78 (0.75–4.25) 0.190
Cluster 4 2.36 (0.85–6.51) 0.096 1.54 (0.55–4.33) 0.404
Cluster 5 2.98 (1.30–6.86) 0.009 1.53 (0.64–3.64) 0.330
Cluster 6 5.78 (2.38–14.07) <0.001 3.63 (1.46–8.99) 0.005
Cluster 7 2.42 (1.04–5.61) 0.039 1.20 (0.49–2.88) 0.683
  1. aModel was unadjusted
  2. bModel was adjusted for age, smoking status, and educational and physical activity levels
  3. In the Cox regression models, cluster 5 and cluster 2 in men and women, respectively, with the lowest incidence rates of cancer (Tables 2 and 3) were considered as reference groups
  4. CI confidence interval, HR hazard ratio