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Table 6 Cluster membership in relation to cancer incidence in Iranian population in the Tehran Lipid and Glucose Study (1999–2014)

From: Sex-specific clustering of metabolic risk factors and cancer risk: a longitudinal study in Iran

 

Model 1a

Model 2b

HR

(95% CI)

P value

HR

(95% CI)

P value

Men

Cluster 5

Reference

–

–

Reference

–

–

Cluster 1

5.38

(1.89–15.33)

0.002

2.56

(0.89–7.39)

0.080

Cluster 2

5.17

(1.73–15.49)

0.003

2.65

(0.87–8.03)

0.083

Cluster 3

7.75

(2.73–22.01)

0.003

3.56

(1.23–10.28)

0.018

Cluster 4

4.76

(1.66–13.61)

0.001

2.46

(0.85–7.11)

0.096

Cluster 6

2.60

(0.78–8.63)

0.118

3.05

(0.91–10.14)

0.068

Cluster 7

2.58

(0.87–7.65)

0.085

2.23

(0.75–6.62)

0.146

Women

Cluster 2

Reference

–

–

Reference

–

–

Cluster 1

2.92

(1.28–6.63)

0.010

2.23

(0.97–5.13)

0.057

Cluster 3

2.32

(0.98–5.49)

0.054

1.78

(0.75–4.25)

0.190

Cluster 4

2.36

(0.85–6.51)

0.096

1.54

(0.55–4.33)

0.404

Cluster 5

2.98

(1.30–6.86)

0.009

1.53

(0.64–3.64)

0.330

Cluster 6

5.78

(2.38–14.07)

<0.001

3.63

(1.46–8.99)

0.005

Cluster 7

2.42

(1.04–5.61)

0.039

1.20

(0.49–2.88)

0.683

  1. aModel was unadjusted
  2. bModel was adjusted for age, smoking status, and educational and physical activity levels
  3. In the Cox regression models, cluster 5 and cluster 2 in men and women, respectively, with the lowest incidence rates of cancer (Tables 2 and 3) were considered as reference groups
  4. CI confidence interval, HR hazard ratio