From: Sex-specific clustering of metabolic risk factors and cancer risk: a longitudinal study in Iran
Variables | Cluster 1 (n = 946) | Cluster 2 (n = 639) | Cluster 3 (n = 764) | Cluster 4 (n = 302) | Cluster 5 (n = 804) | Cluster 6 (n = 270) | Cluster 7 (n = 939) | P value |
---|---|---|---|---|---|---|---|---|
Age (years) | 42.4(12.1) | 38.5(6.6) | 43.3(9.8) | 46.7(10.5) | 52.0(10.9) | 48.2(10.9) | 53.6(10.4) | <0.001 |
Education | ||||||||
 Level 1 (0–8 years) | 724(76.5) | 542(84.8) | 637(83.4) | 233(77.2) | 580(72.1) | 203(75.2) | 649(69.1) | <0.001 |
 Level 2 (9–11 years) | 128(13.6) | 73(11.4) | 66(8.6) | 23(7.6) | 24(3.0) | 10(3.7) | 24(2.6) | |
 Level 3 (> 12 years) | 94(9.9) | 24(3.8) | 61(8.0) | 46 (15.2) | 200 (24.9) | 57(21.1) | 266(28.3) | |
Physical activity level | ||||||||
 Low physical activity | 681(72.0) | 425(66.5) | 536(70.2) | 205(67.9) | 580(72.1) | 186(68.9) | 700(74.5) | 0.019 |
Smoking | ||||||||
 Never | 710(75.1) | 468(73.2) | 541(70.8) | 228(75.5) | 631(78.5) | 177(65.6) | 722(76.9) | <0.001 |
 Past | 14(1.5) | 7(1.1) | 14(1.9) | 2(0.7) | 31(3.8) | 13(4.8) | 32(3.4) | |
 Passive | 168(17.7) | 119(18.7) | 169(22.1) | 58(19.2) | 118(14.7) | 63(23.3) | 153(16.3) | |
 Current | 54(5.7) | 45(7.0) | 40(5.2) | 14(4.6) | 24(3.0) | 17(6.3) | 32(3.4) |  |
BMI (kg/m2) | 22.6(1.8) | 29.2(3.2) | 29.6(3.4) | 30.3(4.1) | 30.6(3.8) | 30.4(4.5) | 30.4(4.7) | <0.001 |
FPG (mmol/L) | 5.0(1.3) | 4.8(0.3) | 4.8(.3) | 0.3(2.4) | 4.9(0.4) | 7.1(2.3) | 7.9(3.2) | <0.001 |
TC (mmol/L) | 5.1(1.1) | 4.4(0.5) | 6.2(0.9) | 4.6(0.4) | 6.4(0.9) | 4.6(0.4) | 6.6(1.1) | <0.001 |
SBP (mmHg) | 111.2(16.5) | 106.5(7.5) | 108.1(7.7) | 132.7(13.0) | 137.1(16.5) | 125.3(17.5) | 135.1(22.5) | <0.001 |
Mean number of risk factors | 0.8(0.7) | 1.0(0.0) | 2.0 (0.0) | 2.0 (0.0) | 3.0 (0.0) | 2.5(0.5) | 3.6(0.4) | <0.001 |
HBMI | (0.0) | 639(100) | 764(100) | 302(100) | 804(100) | 250(92.6) | 850(90.5) | <0.001 |
HSBP | 210(22.2) | 0(0.0) | 0 (0.0) | 302(100) | 804(100) | 161(59.6) | 718(76.5) | <0.001 |
HTC | 436(46.1) | 0(0.0) | 764(100) | 0(0.0) | 804(100) | 0(0.0) | 939(100) | <0.001 |
HFPG | 73(7.7) | 0(0.0) | 0(0.0) | 0(0.0) | 0(0.0) | 270(100) | 939(100) | <0.001 |
Number of events | 31 | 7 | 20 | 8 | 27 | 16 | 24 | Â |
Incident rate of cancers (CI), per 1000 person years | 2.6(1.8–3.7) | 0.8(0.4–1.8) | 2.1(1.3–3.2) | 2.1(1.0–4.2) | 2.6(1.8–3.8) | 5.0 (3.0–8.2) | 2.1(1.4–3.1) |  |