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Table 4 Differentially expressed miRNAs in peripartum cardiomyopathy

From: Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs

miRNARegulation in human pregnancyRef.Heart diseaseMechanism and outcomeRef.
miR-146a↑ plasma[62, 198]Cardiomyocyte-restricted STAT3-KO mice↑miR-146a → ↓NRAS →
↓ EC proliferation, ↑ apoptosis
↑ miR-146a in cardiomyocytes →
↓ ERBB4 → ↓ metabolic activity
miR-199a↑ LV tissue[61, 199]Cardiomyocyte-restricted STAT3-KO mice↑miR-199a-5p → ↓ERBB4 in cardiomyocytes → ↓glucose uptake, ↑ROS, ↑cell death[199]
↑miR-199a-5p → ↓ Ube2g1/Ube2i → cardiomyocyte sarcomere disarray
↑miR-199a-5p → ↑ ADMA secretion from cardiomyocytes → ↓ NO bioavailability, ↑ cardiac EC dysfunction, ↑ apoptosis
  1. ADMA asymmetric dimethylarginie, EC endothelial cell, ERBB4 Erb-B2 receptor tyrosine kinase 4, KO knockout, LV left ventricle, miR microRNA, NO nitric oxide, NRAS NRAS proto-oncogene, ROS reactive oxygen species, STAT3 signal transducer and activator of transcription 3, Ube2g1 ubiquitin-conjugating enzyme E2 G1, Ube2i ubiquitin-conjugating enzyme E2 I, UPS ubiquitin-proteasome system