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Table 3 Differentially expressed circulating miRNAs in gestational hypertension and their effects in heart disease

From: Pregnancy-associated cardiac dysfunction and the regulatory role of microRNAs

miRNARegulation in human pregnancyRef.Heart diseaseMechanism and outcomeRef.
miR-29a↑ serum[194]Patients with hypertrophic cardiomyopathy↑ miR-29a → ↑ cardiac hypertrophy, ↑fibrosis[169, 170]
Mouse TAC↓ miR-29a → ↓ cardiac hypertrophy, ↓fibrosis[170]
ET-1 in H9c2 cardiomyocytes↓ NFATc4 → ↓ cardiomyocyte hypertrophy[171]
miR-125-5p↓ plasma[184]Mouse LAD ligation↓ bak1, ↓ klf13 →
↓ cardiomyocyte apoptosis
miR-181a↑ serum[194]Human with AMI or unstable angina↑ oxidative stress marker lipid hydroperoxide[195]
Rat LAD ligation↓ TGF-β type III receptor in cardiac fibroblasts → ↑ collagen I, ↑ fibronectin[196]
Rat abdominal aortic constriction↓ miR-181a → ↑ ATG5 → ↑ hypertrophy[197]
  1. AMI acute myocardial infarction, ATG5 autophagy-related 5, GH gestational hypertension, LAD left anterior descending, MI myocardial infarction, miR microRNA, TGF-β transforming growth factor-beta