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Fig. 8 | Biology of Sex Differences

Fig. 8

From: Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression- and anxiety-like behaviors

Fig. 8

Differences between male and female rats in the Akt/GSK3/β-catenin signaling pathway. Modulation of Akt. Phosphorylation of Akt at Ser473 (a) and Thr308 (b). At basal level, Akt was more active (more phosphorylated) in male than in female (p < 0.0001) for both sites. SKF 83959 increased the phosphorylation of Akt on both sites, pThr308-Akt (a) and pSer473-Akt (b), in female rats. Pre-treatment with TAT-D1 peptide blocked the SKF 83959 effects on pSer473 but had no notable effect on pThr308 site in female rats. No effect of treatment was observed in the NAc of male rats. N = 6 rats/group. Data are means ± SEM

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Biology of Sex Differences

ISSN: 2042-6410

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