Fig. 4

Sex difference in low-frequency oscillations recorded from NAc of animals exposed to SKF 83959. Local field potential (LFP) recordings from NAc were taken for the duration of each test for each animal subjected to the EPM after low doses (0, 0.1, 0.25 mg/kg) of SKF 83959 as indicated in Fig. 3. a Power spectra from male and female rats treated with vehicle or SKF 83959 (0.1 and 0.25 mg/kg). b Quantification of power spectra showing that female rats, but not male rats, exhibited a reduction in low-frequency delta in NAc in response to both doses of SKF 83959. c Quantification of power spectra showing a reduction in low-frequency theta oscillations in NAc of female rats only by 0.25 mg/kg SKF 83959. d Quantification of power spectra showing no sex difference in beta frequency oscillations in NAc. e Quantification of power spectra showing no sex difference in low-gamma frequency oscillations. f Quantification of power spectra showing innately lower NAc high gamma power in female rats compared to male rats. Error bars represent means ± SEM. ⁺p < 0.05, ⁺⁺p < 0.01 compared to female rats of the same dose, Student’s t test. **p < 0.01, ***p < 0.001, compared to vehicle-treated rats of the same sex, paired Student’s t test. N = 5–6/group with 2 electrodes/rat