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Table 4 Abundance of sex-biased expression of X/Y-linked DEF-defined ISRG

From: SeXY chromosomes and the immune system: reflections after a comparative study

  

Sex bias, n (%)*

Gene type and XCI status*

ISRG, n

No data

Male

Female

No bias

PAR

8

1 (12.5)

6 (75.0)

0 (0)

1 (12.5)

 XCI escape (PAR1)

6

1 (16.7)

5 (83.3)

  

 XCI (PAR2)

2

 

1 (50.0)

 

1 (50.0)

Non-PAR X-linked *

46

 

3 (6.5)

11 (23.9)

32 (69.6)

 XCI (mainly)

31

 

1 (3.2)

8 (25.8)

22 (71.0)h

 XCI escape (variable)

11

 

1 (9.1)

3 (27.3)

7 (63.6)

 Discordant /unknown

4

 

1 (25.0)

0 (0)

3 (75.0)

TOTAL X-linked

54

1 (1.9)*

9 (16.7)

11 (20.4)

33 (61.1)

Non-PAR Y-linked candidate ISRG

(2)

NA

2 (100)

NA

NA

Non-PAR X-linked paralogs XCI escape

(2)

  

2 (100)

 
  1. XCI X chromosome inactivation, XCI status and sex-biased expression according to Tukiainen [29]; *, there were insufficient data on the expression of this gene to properly analyse expression bias; h, the numbers include MPP1, which displayed a heterogeneous sex bias