Fig. 1

Three comparative approaches to evaluate the relative abundance of human X/Y-linked coding immune genes. DEF approach: Genes on X and Y chromosomes were annotated based on three criteria: disease, tissue expression, and function (DEF approach). Details are explained in the Methods section. Genome-wide genes were selected by either a) an elevated expression in lymphoid tissue (LTEEG approach) or b) the ´Immune System Process´-annotation, GO:0002376 (GO approach), followed by an analysis of the distribution of the LTEEG and GO genes over the chromosomes. Data were obtained from the following databases: HGNC [18], e!Ensembl [19], GeneCards [20] (Genomics, Function, Expression, and Disorders), BioGPS (U133A GeneAtlas, Primary Cell Atlas) [21], the Human Protein Atlas [22], Bgee [23], and AmiGO 2 [24]