XCI-informed | XCI-robust | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | SNP | Alleles (min/maj) | Nearest gene | Cohort | MAF | Chosen XCI status | ORM | ORW1 | ORW2 | P | ORM | ORW1 | ORW2 | P |
Case status | rs5932307 | A/G | ACTRT1 | Mayo | 0.08 | S | 1.59 (1.04–2.43) | 1.26 (1.02–1.56) | 1.59 (1.04–2.43) | 0.03 | 1.39 (0.82–2.36) | 1.42 (1.00–2.02) | 2.02 (1.00–4.08) | 0.06 |
GAIN | 0.07 | S | 1.60 (1.12–2.30) | 1.27 (1.06–1.52) | 1.60 (1.12–2.30) | 0.01 | 1.01 (0.67–1.50) | 3.54 (2.20–5.69) | 12.52 (4.85–32.34) | 6.5E−08 | ||||
Meta | S | 1.60 (1.21–2.10) | 1.26 (1.10–1.45) | 1.60 (1.21–2.10) | 8.2E−04 | 1.13 (0.82–1.56) | 1.96 (1.48−2.60) | 3.86 (2.19–6.78) | 8.3E−08 | |||||
Rapid cycling | rs5933727 | G/C | TBL1X | Mayo | 0.07 | E* | 1.91 (1.19–3.06) | 1.91 (1.19–3.06) | 3.65 (1.42–9.38) | 0.01 | 1.31 (0.56–3.07) | 2.25 (1.26–4.02) | 5.08 (1.60–16.18) | 0.01 |
GAIN | 0.08 | E* | 0.38 (0.23–0.62) | 0.38 (0.23–0.62) | 0.15 (0.05–0.39) | 1.2E−04 | 0.76 (0.34–1.71) | 0.27 (0.14–0.51) | 0.07 (0.02–0.26) | 3.1E−05 | ||||
Meta | E* | 0.77 (0.55–1.08) | 0.77 (0.55–1.08) | 0.60 (0.30–1.18) | 0.14 | 0.99 (0.55–1.77) | 0.86 (0.56–1.31) | 0.73 (0.31–1.73) | 6.2E−06 | |||||
Suicide attempt | rs5975146 | A/G | XPNPEP2 | Mayo | 0.12 | S | 0.47 (0.25–0.85) | 0.68 (0.50–0.92) | 0.47 (0.25–0.85) | 0.01 | 0.10 (0.02–0.45) | 0.99 (0.67–1.46) | 0.98 (0.44–2.15) | 6.2E−04 |
GAIN | 0.11 | S | 1.77 (1.09–2.87) | 1.33 (1.04–1.69) | 1.77 (1.09–2.87) | 0.02 | 1.07 (0.58–1.99) | 2.15 (1.39–3.32) | 4.63 (1.94–11.05) | 1.7E−03 | ||||
Meta | S | 1.05 (0.72–1.53) | 1.02 (0.85–1.24) | 1.05 (0.72–1.53) | 0.80 | 0.76 (0.43–1.33) | 1.40 (1.05–1.88) | 1.97 (1.10–3.53) | 1.5E−05 | |||||
Binge eating | rs6627188 | A/C | CNGA2 | Mayo | 0.14 | S | 0.17 (0.08–0.39) | 0.41 (0.28–0.62) | 0.17 (0.08–0.39) | 2.0E−05 | 0.06 (0.01–0.50) | 0.48 (0.30–0.78) | 0.23 (0.09–0.61) | 4.0E−06 |
GAIN | 0.13 | S | 1.65 (0.86–3.14) | 1.28 (0.93–1.77) | 1.65 (0.86–3.14) | 0.13 | 2.00 (0.76–5.27) | 1.21 (0.78–1.86) | 1.45 (0.61–3.46) | 0.31 | ||||
Meta | S | 0.68 (0.41–1.13) | 0.83 (0.64–1.06) | 0.68 (0.41–1.13) | 0.14 | 1.08 (0.45–2.60) | 0.80 (0.58–1.11) | 0.64 (0.34–1.23) | 1.8E−05 | |||||
Alcohol use disorder | rs145649722 | G/C | CLCN5 | Mayo | 0.04 | S | 0.78 (0.28–2.15) | 0.88 (0.53–1.47) | 0.78 (0.28–2.15) | 0.63 | 0.73 (0.16–3.29) | 0.92 (0.46–1.83) | 0.84 (0.21–3.36) | 0.88 |
GAIN | 0.05 | S | 2.60 (1.24–5.47) | 1.61 (1.11–2.34) | 2.60 (1.24–5.47) | 0.01 | 8.29 (2.50–27.51) | 0.58 (0.29–1.18) | 0.34 (0.08–1.39) | 4.1E−05 | ||||
Meta | S | 1.68 (0.92–3.05) | 1.30 (0.96–1.75) | 1.68 (0.92–3.05) | 0.09 | 3.20 (1.26–8.15) | 0.74 (0.45–1.21) | 0.55 (0.21–1.47) | 4.1E−04 |