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Table 3 Regulation of enzymes involved in bile acid synthesis by hormones and their respective hormone receptors

From: The influence of biological sex and sex hormones on bile acid synthesis and cholesterol homeostasis

Enzyme Hormone/receptor Regulation Reference
CYP7A1 17alpha-ethynylestrodrial (EE2)/ER-alpha Downregulates CYP7A1 expression [123]
GPR30 Upregulates CYP7A1 expression [113]
CYP8B1 17alpha-ethynylestrodrial (EE2)/ER-alpha Downregulates CYP8B1 expression [123[
  Estrogen (with biliary diversion, not intact enterohepatic circulation) Downregulates CYP8B1 expression [124]
CYP27A1 Estrogen/ER-alpha & ER-beta Downregulates CYP27A1 expression [122]
Androgens/androgen receptor Upregulates CYP27A1 expression [122]
CYP3A4 Estrogen Downregulates CYP3A4 [114]
AKR1D1 Testosterone Inhibits upregulation of AKR1D1 by Estrogen [114]