From: The influence of biological sex and sex hormones on bile acid synthesis and cholesterol homeostasis
Major enzymes | Localization | Reaction | Position on Cholesterol | Product |
---|---|---|---|---|
Classical pathway | ||||
CYP7A1 | Endoplasmic Reticulum | Sterol ring modification | C7 | 7a-hydroxycholesterol |
AKR1D1 | Cytosol | Sterol ring modification | C5 | 5b-reduced intermediates |
CYP8B1 | Endoplasmic Reticulum | Sterol ring modification | C12 | 7a, 12a-dihydroxy-4-cholestan-3-one |
CYP27A1 | Mitochondria | Side chain modification | C27 | 27-hydroxycholesterol |
CYP3A4 | Endoplasmic Reticulum | Sterol ring modification | C4 | 4alpha-hydroxy-cholesterol |
Alternative pathway | ||||
CYP27A1 | Mitochondria | Side chain modification | C27 | 27a-hydroxylcholesterol 25a-hydroxycholesterol 24a-hydroxycholesterol |
CYP7B1 | Endoplasmic Reticulum | Sterol ring modification | C7 | 7a-hydroxylated intermediates |
AKR1D1 | Cytosol | Â | Â | 5b-reduced intermediates |
CYP27A1 | Mitochondria | Side chain modification | C27 | CDCA |